ArticleScientific reports2026
Photoprotective zoanthamine derivatives from the cultured zoantharian zoanthus sansibaricus.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Zoanthus sansibaricus is a marine invertebrate native to the Indian and North Pacific Oceans. A chemical investigation of Z. sansibaricus, cultured in an aquafarm, led to the isolation of two new zoanthamine derivatives, named 3β-hydroxyzoanthamine (1) and 3α-hydroxynorzoanthaminone (2), along with five known derivatives (3‒7). Their structures were elucidated through quantum chemical calculations and a detailed analysis of spectroscopic data, including mass, IR, and NMR spectra. New compounds 1 and 2 represent additional examples of the oxidation of zoanthamine derivatives. The potential photoprotective effect of all isolated alkaloids (1‒7) was evaluated against UVA-induced damage in human dermal fibroblasts. Among the tested compounds, only 26-norzoanthamine (4) significantly attenuated UVA-induced oxidative stress. Notably, this antioxidant activity did not translate into sustained cell viability protection at 72 hours post-irradiation, suggesting that the photoprotective mechanism of compound 4 is limited to acute oxidative stress attenuation.
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