Evidence map›Paper›PMID 42067562›Full record

ArticleNature communications2026

Activating p53

Xijun Zhu, Woong Sub Byun, Dominika Ewa Pieńkowska, Kha The Nguyen, Mengxiong Wang, Sabin A Nettles, Sai Gourisankar, Nick A Phillips, Jan Gerhartz, Qixiang Geng and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Xijun Zhu *Department of Chemistry, Stanford University, Stanford, CA, USA.
Woong Sub Byun *Department of Chemical and Systems Biology, ChEM-H, Stanford Cancer Institute, School of Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-4676-3698
Dominika Ewa Pieńkowska *Institute of Structural Biology, Medical Faculty, University of Bonn, Bonn, Germany.
Kha The NguyenDepartment of Radiation Oncology, Division of Radiation and Cancer Biology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-9191-8754
Mengxiong WangDepartment of Radiation Oncology, Division of Radiation and Cancer Biology, Stanford University School of Medicine, Stanford, CA, USA.
Sabin A NettlesDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Sai GourisankarDepartment of Chemical and Systems Biology, ChEM-H, Stanford Cancer Institute, School of Medicine, Stanford University, Stanford, CA, USA.
Nick A PhillipsCancer Biology Program, Stanford School of Medicine, Stanford University, Stanford, CA, USA.
Jan GerhartzInstitute of Structural Biology, Medical Faculty, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0009-0002-9457-4656
Qixiang GengDepartment of Chemical and Systems Biology, ChEM-H, Stanford Cancer Institute, School of Medicine, Stanford University, Stanford, CA, USA.
Tian QiuDepartment of Chemical and Systems Biology, ChEM-H, Stanford Cancer Institute, School of Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-7168-0715
Jianing ZhongDepartment of Chemistry, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0009-0005-8330-0053
Zixuan JiangDepartment of Chemistry, Stanford University, Stanford, CA, USA.
Roman C SarottDepartment of Chemical and Systems Biology, ChEM-H, Stanford Cancer Institute, School of Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-8789-6150
Stephen M HinshawDepartment of Chemical and Systems Biology, ChEM-H, Stanford Cancer Institute, School of Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-4215-5206
Tinghu ZhangDepartment of Chemical and Systems Biology, ChEM-H, Stanford Cancer Institute, School of Medicine, Stanford University, Stanford, CA, USA.
Laura D AttardiDepartment of Radiation Oncology, Division of Radiation and Cancer Biology, Stanford University School of Medicine, Stanford, CA, USA. attardi@stanford.edu.ORCID http://orcid.org/0000-0003-1782-9045
Radosław P NowakInstitute of Structural Biology, Medical Faculty, University of Bonn, Bonn, Germany. radoslaw.nowak@uni-bonn.de.ORCID http://orcid.org/0000-0002-0605-0071
Nathanael S GrayDepartment of Chemical and Systems Biology, ChEM-H, Stanford Cancer Institute, School of Medicine, Stanford University, Stanford, CA, USA. nsgray01@stanford.edu.ORCID http://orcid.org/0000-0001-5354-7403

Funding

U.S. Department of Health & Human Services | National Institutes of Health (NIH) 1S10OD028697-01
6 · The paper itself

Abstract

TP53 is the most commonly mutated gene in cancer, but it remains recalcitrant to clinically meaningful therapeutic reactivation. We present here the discovery and characterization of a small molecule chemical inducer of proximity that activates mutant p53. We named this compound TRanscriptional Activator of p53 (TRAP-1) due to its ability to engage p53

Indexed as

Small Molecule LibrariesTumor Suppressor Protein p53ApoptosisBromodomain Containing ProteinsCell Cycle ProteinsCell Line, TumorCellular SenescenceCyclin-Dependent Kinase Inhibitor p21HumansMutationNuclear ProteinsTranscriptional ActivationTranscription FactorsBRD4 protein, humanBromodomain Containing ProteinsCDKN1A protein, humanCell Cycle ProteinsCyclin-Dependent Kinase Inhibitor p21Nuclear ProteinsSmall Molecule LibrariesTP53 protein, humanTranscription FactorsTumor Suppressor Protein p53

Identifiers

PMID42067562
PMCPMC13342671

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.