Evidence map›Paper›PMID 42066770›Full record

ArticleCell reports. Medicine2026

Escherichia coli Nissle 1917 alleviates Alzheimer's disease in mice through OmpA-containing outer membrane vesicles.

Junhua Xie, Xi-Jian Dai, Qiqiong Li, Wanyu Zhang, Xinke Nie, Haihua Ji, Xinyang Chen, Yuchen Wang, Jing Feng, Zhipeng Li and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Junhua XieState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, Jiangxi, China.
Xi-Jian DaiDepartment of Radiology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China; Jiangxi Provincial Key Laboratory of Intelligent Medical Imaging, Nanchang 330006, China; Nanchang Key Laboratory of Medical-Engineering Integration and Clinical Translation, Nanchang 330006, China.
Qiqiong LiState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, Jiangxi, China.
Wanyu ZhangState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, Jiangxi, China.
Xinke NieState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, Jiangxi, China.
Haihua JiState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, Jiangxi, China.
Xinyang ChenState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, Jiangxi, China.
Yuchen WangCollege of Food Science and Technology, Nanchang University, Nanchang 330031, China.
Jing FengCollege of Food Science and Technology, Nanchang University, Nanchang 330031, China.
Zhipeng LiCollege of Food Science and Technology, Nanchang University, Nanchang 330031, China.
Qiong LiuDepartment of Medical Microbiology, School of Medicine, Nanchang University, Nanchang 330006, China.
Jianxin YeInstitute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Guangzhi ZhangInstitute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Shaoping NieState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, Jiangxi, China. Electronic address: spnie@ncu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut microbiota dysbiosis is a driving factor in Alzheimer's disease (AD), yet the mechanisms behind remain elusive. Emerging evidence highlights that outer membrane vesicles (OMVs) are critical mediators of microbiota-host communication. Here, we observed a reduction in a gut probiotic Escherichia coli Nissle 1917 (EcN)-like strain in AD patients, and its levels are positively associated with cognitive ability. The EcN OMVs containing outer membrane protein A (OmpA) translocate to the brain, reshaping the dysregulated immune network. Specifically, EcN OMVs are internalized by glia and neurons, suppressing glial hyperactivation and restoring synaptic function, thereby reducing Aβ deposition and cognitive deficits. The results further show that OmpA plays an important role in vesicle trafficking and inflammatory pathways and may be the key regulator of inflammatory mediators in EcN OMVs, modulating astrocyte-microglia-neuron interactions and functionality. This work discloses the substantial therapeutic potential of the probiotic and its secreted OMVs in intervention and treatment of neurological disorders.

Indexed as

Alzheimer DiseaseBacterial Outer Membrane ProteinsEscherichia coliProbioticsAnimalsAstrocytesBrainDisease Models, AnimalFemaleGastrointestinal MicrobiomeHumansMaleMiceMice, Inbred C57BLMicrogliaNeuronsBacterial Outer Membrane ProteinsOMPA outer membrane proteinsAlzheimer’s diseaseEscherichia coli Nissle 1917gut-brain axisgut microbiotaneuro-immune interactionouter membrane protein Aouter membrane vesiclesprobioticsynaptic dysfunctionvagus nerve

Identifiers

PMID42066770
PMCPMC13198242

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.