ArticleCancer cell2026
Activated T cell extracellular vesicle DNA transfer enhances antigen presentation and anti-tumor immunity.
Abstract read
In one paragraph
Article in Cancer cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Nanomaterials-Based Immunotherapy for Atherosclerosis.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Review
- Message in a vesicle: T cells boost tumour immunity.Nature reviews. Cancer · 2026Article
- T cell-derived extracellular vesicles promote antitumour immunity through horizontal gene transfer.Nature reviews. Immunology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
45 authors.
Mengying HuChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
Di-Ao LiuChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Inbal WortzelChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Paul CollierDepartment of Physiology, Biophysics, and Systems Biology, Weill Cornell Medicine, New York, NY, USA.
Theodore M NelsonDepartment of Physiology, Biophysics, and Systems Biology, Weill Cornell Medicine, New York, NY, USA.
Jonathan FooxDepartment of Physiology, Biophysics, and Systems Biology, Weill Cornell Medicine, New York, NY, USA.
Guojie ZhongDepartment of Systems Biology, Columbia University, New York, NY, USA.
Gabriel TobiasChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Tetsuhiko AsaoChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Thoracic Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Respiratory Medicine, Juntendo University, Tokyo, Japan.
Linda BojmarChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Candia M KenificChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Gang WangChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Simone CaielliDrukier Institute for Children's Health and Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Zurong WanDrukier Institute for Children's Health and Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Sarah QureshyChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Max ReedChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Richard PiszczatowskiChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Purnima RavisankarDrukier Institute for Children's Health and Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Julia A BrownDrukier Institute for Children's Health and Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Sihan XiongChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Huajuan WangChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Pernille LauritzenChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Yael AylonDepartment of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel.
Henrik MolinaProteomics Resource Center, The Rockefeller University, New York, NY 10065, USA.
William R JarnaginHepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Moshe OrenDepartment of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel.
Ben Z StangerDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jack BuiDepartment of Pathology, University of California, San Diego, La Jolla, CA, USA.
Gabriele BergersLaboratory of Tumor Microenvironment and Therapeutic Resistance, KU Leuven, Leuven, Belgium.
Agnès NoëlLaboratory of Biology of Tumor and Development, Université de Liège, Liège, Belgium.
Paul M GrandgenettEppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
Michael A HollingsworthEppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
David TuvesonCancer Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY 11724, USA.
Nancy BoudreauChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Jacqueline BrombergDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
David KelsenGastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
David R JonesThoracic Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Laura SantambrogioDepartment of Radiation Oncology, Weill Cornell School of Medicine, New York, NY, USA.
Melody Y ZengDrukier Institute for Children's Health and Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Virginia PascualDrukier Institute for Children's Health and Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Han Sang KimChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Yonsei Cancer Center, Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Christopher E MasonDepartment of Physiology, Biophysics, and Systems Biology, Weill Cornell Medicine, New York, NY, USA.
Haiying ZhangChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. Electronic address: haz2005@med.cornell.edu.
Irina R MateiChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. Electronic address: irm2224@med.cornell.edu.
David LydenChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. Electronic address: dcl2001@med.cornell.edu.
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MPancreatic Cancer Detection ConsortiumU01CA210240 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Michael A. Hollingsworth · 2017 to 2026
$12.9MSystemic regulation of metastasisR35CA232093 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LYDEN, DAVID CHARLES · 2018 to 2024
$7.0MDevelopment and application of asymmetric-flow field-flow (AF4) technology in fractionation and characterization of exosome subpopulations and novel nanoveiscles in pancreatic cancer modelR01CA218513 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Jacob Geri, DAVID CHARLES LYDEN · 2017 to 2026
$4.3MNCI NIH HHS P30 CA008748NCI NIH HHS R01 CA218513NCI NIH HHS R35 CA232093NCI NIH HHS U01 CA210240
Abstract
Antigen processing and presentation (APP) is essential for adaptive immunosurveillance. We uncover a mechanism whereby activated T cell-derived extracellular vesicles (AT
Indexed as
Antigen PresentationExtracellular VesiclesLymphocyte ActivationT-LymphocytesAnimalsCytosolDendritic CellsDNAFemaleHomeostasisMajor Histocompatibility ComplexMiceMice, Inbred BALB CMice, Inbred C57BLNeoplasmsSpleenDNAacellular immunotherapyactivated T cell-derived EVsantigen presentationEV(DNA)gene transfer
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.