Evidence map›Paper›PMID 42066087›Full record

ArticleScience advances2026

Spliceosomal mutation drives melanoma tumorigenesis via lineage-specific RAS activation.

Ruixin Jiang, Peiqi Xing, Jindou Xie, Gang Bai, Yuzhu Zhang, Pengcong Hou, Hao Luo, Yanni Ma, Ruixin Liu, Yang Zheng and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Ruixin JiangDepartment of Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0009-0005-0246-1964
Peiqi XingDepartment of Computational Biology, China National Center for Bioinformation, Beijing, China.ORCID 0000-0002-5675-1036
Jindou XieDepartment of Computational Biology, China National Center for Bioinformation, Beijing, China.ORCID 0009-0009-1656-6600
Gang BaiShanghai Institute of Precision Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yuzhu ZhangShanghai Institute of Precision Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-2746-0096
Pengcong HouShanghai Institute of Precision Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hao LuoShanghai Institute of Precision Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yanni MaShanghai Institute of Precision Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ruixin LiuShanghai Institute of Precision Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yang ZhengDepartment of Oral and Maxillofacial-Head Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
Xiangyu ChenDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Bin JiangDepartment of Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jing HuangShanghai Institute of Precision Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yanjie ZhangDepartment of Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-7425-8632
A Hunter ShainDepartment of Dermatology, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-2999-9706
Ming LeiShanghai Institute of Precision Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-1153-4791
Robert L Judson-TorresHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0002-6559-0553
Jing YeGeriatric Department, Geriatric Medical Center, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhaoqi LiuDepartment of Computational Biology, China National Center for Bioinformation, Beijing, China.ORCID 0000-0002-3798-9583
Hanlin ZengDepartment of Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-6904-5261

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in splicing factors are recurrent across human cancers and drive widespread RNA splicing dysregulation. Among these,

Indexed as

Melanomaras ProteinsRNA Splicing FactorsAnimalsCell Line, TumorHumansMaleMiceMice, Inbred NODNeurofibromin 1PhosphoproteinsRNA SplicingSpliceosomesNeurofibromin 1Phosphoproteinsras ProteinsRNA Splicing FactorsSF3B1 protein, humanSf3b1 protein, mouse

Identifiers

PMID42066087
PMCPMC13134632

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.