ArticleAnalytical chemistry2026
A Multidimensional Workflow for Comprehensive Xenometabolome Profiling by Integrating TIMS-PASEF with LC-HRMS and Biotransformation-Informed Suspect and Nontarget Screening.
Article in Analytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Comprehensive xenometabolome characterization is essential for understanding the effects of xenobiotics in biological systems. This study presents a multidimensional analytical workflow integrating orthogonal chromatographic separations, trapped ion mobility spectrometry (TIMS), high-resolution mass spectrometry and biotransformation-informed data processing to address xenometabolome assessment challenges. Zebrafish larvae exposed to 4-Methylbenzotriazole (4-MeBT) were used as a challenging case study. TIMS dimension provided orthogonal experimental evidence for isomer annotation, with inverse reduced mobility (1/
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