Evidence map›Paper›PMID 42065871›Full record

ArticleJournal of Crohn's & colitis2026

What are the top 10 global research priorities for perianal Crohn's disease? The Global Perianal Crohn's Disease Priority Setting Partnership.

Theo Pelly, Easan Anand, Jonathan Gower, Sameer Mannick, Tom Hough, Sarah Markham, Shaji Sebastian, Christianne Buskens, Jeffrey D Mccurdy, Parakkal Deepak and 16 more

Abstract read
In one paragraph

Article in Journal of Crohn's & colitis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Editorial: Upadacitinib in Perianal Crohn's Disease. Authors' Reply.Alimentary pharmacology & therapeutics · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Theo PellySt Mark's Hospital and Academic Institute, London, United Kingdom.
Easan AnandSt Mark's Hospital and Academic Institute, London, United Kingdom.
Jonathan GowerJames Lind Alliance, United Kingdom.
Sameer MannickPatient representative, United Kingdom.
Tom HoughPatient representative, United Kingdom.
Sarah MarkhamPatient representative, United Kingdom.
Shaji SebastianHull University Teaching Hospital, Hull, United Kingdom.ORCID 0000-0002-3670-6545
Christianne BuskensDepartment of Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0001-9425-8683
Jeffrey D MccurdyUniversity of Ottawa, Ottawa, Canada.ORCID 0000-0002-0658-3062
Parakkal DeepakWashington University in St Louis, St. Louis, MO, United States.ORCID 0000-0002-3436-9784
Amir Reza RadmardDepartment of Radiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.ORCID 0000-0002-7462-118X
Jaap StokerDepartment of Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-9822-3784
Philip LungSt Mark's Hospital and Academic Institute, London, United Kingdom.
Paulo Gustavo KotzeColorectal Surgery Unit, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.ORCID 0000-0002-9632-6691
Lisa YoungeSt Mark's Hospital and Academic Institute, London, United Kingdom.
Denise RobinsonSt Mark's Hospital and Academic Institute, London, United Kingdom.
Shivani JoshiSt Mark's Hospital and Academic Institute, London, United Kingdom.ORCID 0000-0002-6712-1486
Eathar ShakwehSt Mark's Hospital and Academic Institute, London, United Kingdom.
Luke HannaSt Mark's Hospital and Academic Institute, London, United Kingdom.ORCID 0009-0004-8424-202X
Harjeet SinghPost-graduate Institute of Medical Education and Research, Chandigarh, India.
Yarunessa KhanCrohn's and Colitis, United Kingdom.
Katie NightingaleCrohn's and Colitis, United Kingdom.
Nick PowellDivision of Digestive Diseases, Faculty of Medicine, Imperial College London, London, United Kingdom.ORCID 0000-0003-3231-6950
Phil TozerSt Mark's Hospital and Academic Institute, London, United Kingdom.ORCID 0000-0002-2532-7267
Ailsa HartSt Mark's Hospital and Academic Institute, London, United Kingdom.
PSP Collaborators

Funding

The Leona M. and Harry B. Helmsley Charitable Trust
6 · The paper itself

Abstract

BACKGROUND AND

aimsPerianal Crohn's disease (pCD) is a debilitating condition with a prevalence of approximately 20% in patients within 10 years of diagnosis of CD. The condition significantly impacts patient quality of life, and there remain a number of unmet needs relating to its optimal management. A global Priority Setting Partnership (PSP) was established to identify the top 10 research priorities for pCD.

methodsThe PSP followed standard James Lind Alliance (JLA) methodology. An initial survey was circulated to gather unanswered research questions from key stakeholders. From these responses, a longlist of summary questions was formed. These questions were ranked by stakeholders in a second prioritization survey. The highest ranking 19 questions were taken into the final workshop, where a panel of people with lived or professional experience of pCD identified the top 10 research priorities.

resultsOver 1200 individual research questions were submitted by over 400 respondents, from over 30 countries. From the 51 summary questions that were developed from these responses, the top 10 were identified in the final workshop. These included identifying the optimal combined treatment strategy across the full spectrum of pCD, reducing the impact on quality of life, improving timely diagnosis of pCD, identifying a biological classification of pCD, and understanding and managing the impacts on sexual function, intimacy, and relationships.

conclusionsThis global PSP represents a major step towards stakeholder-driven and focused research in pCD. The research priorities provide a roadmap for researchers, funders and policy-makers to align future research with patient and clinician needs to improve outcomes.

Indexed as

Anus DiseasesBiomedical ResearchCrohn DiseaseGlobal HealthInternational CooperationHumansNeeds AssessmentCrohn’s disease

Identifiers

PMID42065871
PMCPMC13134380

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.