Evidence map›Paper›PMID 42065820›Full record

ArticleCell biology and toxicology2026

DNAJB4/HLJ1 protects against acetaminophen-induced liver injury by attenuating ER stress via HSP70.

Chih-Yun Lu, Tsung-Hsuan Hsieh, Min-Hui Chien, Wei-Lun Hsu, Wei-Jia Luo, Jung-Hsuan Chang, Chia-I Lee, Yi-Chun Chen, Cheng-Hao Fang, Ching-Hua Kuo and 2 more

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In one paragraph

Article in Cell biology and toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chih-Yun LuDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Tsung-Hsuan HsiehDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Min-Hui ChienDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Wei-Lun HsuDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Wei-Jia LuoDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Jung-Hsuan ChangDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chia-I LeeDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Yi-Chun ChenDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Cheng-Hao FangDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Ching-Hua KuoDepartment of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Sung-Liang YuDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan. slyu@ntu.edu.tw.ORCID 0000-0003-4535-9036
Kang-Yi SuDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan. suky@ntu.edu.tw.ORCID 0000-0002-6538-9526

Funding

National Science and Technology Council NSTC 114-2320-B-002-066-MY3
6 · The paper itself

Abstract

Drug-induced liver injury (DILI) remains a leading cause of acute liver failure; however, current clinical strategies lack reliable biomarkers, predictors of susceptibility, and effective therapeutic interventions. Among these etiologies, acetaminophen (APAP) overdose is the most common cause of DILI worldwide. Heat shock proteins (HSPs), particularly members of the HSP40 family, are central regulators of cellular stress responses, yet the specific role of DNAJB4/HLJ1 in APAP-induced hepatotoxicity remains poorly defined. To address this gap, we employed DNAJB4/HLJ1-deficient mice (Dnajb4

Indexed as

AcetaminophenChemical and Drug Induced Liver InjuryEndoplasmic Reticulum StressHSP40 Heat-Shock ProteinsHSP70 Heat-Shock ProteinsAnimalsLiverMaleMiceMice, Inbred C57BLMice, KnockoutAcetaminophenHSP40 Heat-Shock ProteinsHSP70 Heat-Shock ProteinsAcetaminophenAcute liver failureDNAJB4Drug-induced liver injuryER stressHeat shock proteins

Identifiers

PMID42065820
PMCPMC13279685

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.