Evidence map›Paper›PMID 42065812›Full record

ArticleIrish journal of medical science2026

Evaluation of liver function and related factors in patients with chronic hepatitis B-related cirrhosis complicated with esophagogastric variceal bleeding.

Yue Feng, Bei Li, Yueyong Zhu, Biguang Tuo, Yiling Li, Die Huang, Lu Zhou, Yuhan Du, Hui Liu, Yu Dong and 6 more

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Article in Irish journal of medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

16 authors.

Yue FengDepartment of Gastroenterology, Beijing TongRen Hospital, Capital Medical University, No. 1, Dongjiaominxiang, Dongcheng District, Beijing, 100730, China.
Bei LiDepartment of Gastroenterology, Beijing TongRen Hospital, Capital Medical University, No. 1, Dongjiaominxiang, Dongcheng District, Beijing, 100730, China.
Yueyong ZhuDepartment of Hepatology, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350005, China.
Biguang TuoDepartment of Gastroenterology, Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou, 563003, China.
Yiling LiDepartment of Gastroenterology, The First Affiliated Hospital of China Medical University, Liaoning, 110001, China.
Die HuangDepartment of Gastroenterology, The First Affiliated Hospital of China Medical University, Liaoning, 110001, China.
Lu ZhouDepartment of Gastroenterology and Hepatology, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin Medical University General Hospital, Tianjin, 300000, China.
Yuhan DuDepartment of Gastroenterology and Hepatology, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin Medical University General Hospital, Tianjin, 300000, China.
Hui LiuDepartment of Gastroenterology, Shandong Provincial Hospital, Shandong University, Jinan, 250021, China.
Yu DongDepartment of Gastroenterology, Shandong Provincial Hospital, Shandong University, Jinan, 250021, China.
Ling LanDepartment of Gastroenterology and Hepatology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, 450003, China.
Yuhan LouDepartment of Gastroenterology and Hepatology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, 450003, China.
Shaoqi YangDepartment of Gastroenterology, General Hospital of Ningxia Medical University, Yinchuan, 750004, China.
Weifang MaDepartment of Gastroenterology, General Hospital of Ningxia Medical University, Yinchuan, 750004, China.
Chuan ZhangDepartment of Gastroenterology, Beijing TongRen Hospital, Capital Medical University, No. 1, Dongjiaominxiang, Dongcheng District, Beijing, 100730, China. doctor_zhang11@163.com.
Yutao ZhanDepartment of Gastroenterology, Beijing TongRen Hospital, Capital Medical University, No. 1, Dongjiaominxiang, Dongcheng District, Beijing, 100730, China. zhan12690@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study intended to evaluate liver function and related factors in patients with chronic hepatitis B (CHB)-related cirrhosis complicated with esophagogastric variceal bleeding (EGVB).

methodsPatients with CHB-related cirrhosis complicated with EGVB were screened from the multicenter database. Patients were divided into Child-Pugh A, B, and C based on Child-Pugh scores. Clinical characteristics and laboratory findings were collected to explore factors affecting good liver function (Child-Pugh A: good liver function; Child-Pugh B or C: poor liver function).

resultsA total of 356 eligible patients were included after applying predefined inclusion and exclusion criteria from an initial multicenter cohort, including 62 (17.4%) patients with Child-Pugh A, 233 (65.5%) with Child-Pugh B, and 61 (17.1%) with Child-Pugh C. Aspartate transaminase, creatinine, and viral marker status differed significantly among groups. No difference was found in clinical characteristics or laboratory indexes except for Child-Pugh indexes among patients with Child-Pugh A, B, and C. HBsAg (+), HBeAg (+), and Anti-HBc (+) and creatinine were independently and negatively related to good liver function.

conclusionPatients with CHB-related cirrhosis complicated with EGVB show different degrees of liver dysfunction, and they are suggested to be classified into three subtypes A, B, and C according to Child-Pugh classification. HBsAg (+), HBeAg (+), and Anti-HBc (+) is related to poor liver function, and positive antiviral therapy may be beneficial for the prevention of liver function damage in these patients.

Indexed as

CirrhosisEsophagogastric variceal bleedingLiver functionPortal hypertensionRisk factors

Identifiers

PMID42065812

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.