Evidence map›Paper›PMID 42065737›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026

Multimodal evaluation of choroidal vascular alterations after panretinal photocoagulation in diabetic retinopathy.

Areum Jeong, Ye Eun Han, Leegoni Choi, Dahye Jung, Yulim Kim, Min Sagong, Junyeop Lee

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PubMed Full text at PMC Publisher
In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Areum Jeong *Department of Ophthalmology, College of Medicine, Yeungnam University, Daegu, South Korea.
Ye Eun Han *Department of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.
Leegoni ChoiDepartment of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.
Dahye JungDepartment of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.
Yulim KimDepartment of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.
Min SagongDepartment of Ophthalmology, College of Medicine, Yeungnam University, Daegu, South Korea.
Junyeop LeeDepartment of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea. j.lee@amc.seoul.kr.

Funding

Asan Institute for Life Sciences, Asan Medical Center 2023IP0079-3Korea Health Industry Development Institute RS-2024-00438689
6 · The paper itself

Abstract

purposeTo evaluate morphological and quantitative changes in the choroid after panretinal photocoagulation (PRP) for diabetic retinopathy using multimodal imaging and to identify factors associated with these changes.

methodsThis retrospective study included 48 eyes of 26 patients with severe non-proliferative or proliferative diabetic retinopathy. Ultra-widefield indocyanine green angiography (UWF-ICGA) and enhanced-depth imaging optical coherence tomography (EDI-OCT) were performed before and after PRP. Choroidal vessel density, fractal dimension (FD), and hyperpermeable area were quantified from fluorescein angiography-subtracted ICGA images using ImageJ and Fractalyse software. Choroidal vascularity index (CVI), subfoveal choroidal thickness (SFCT), and Haller's layer thickness were measured on EDI-OCT. CVI was calculated as the ratio of the luminal area to the total subfoveal choroidal area within a 1,500-µm region. Relationships among choroidal and retinal parameters were analyzed by multivariable regression.

resultsAfter PRP, the mean hyperpermeable area significantly decreased (8.78%→7.95%, p < 0.001), accompanied by reductions in choroidal vessel density (34.67%→33.34%, p < 0.001), FD (1.662→1.632, p = 0.003), SFCT (266.63→242.75 μm, p < 0.001), and CVI (64.34%→62.13%, p < 0.001). Haller's layer thickness was independently associated with the hyperpermeable area, while CVI correlated with central retinal thickness and Haller's layer thickness.

conclusionPRP reduces choroidal vascular congestion and complexity, suggesting structural remodeling of the choroidal vasculature associated with reduced vascular permeability. Quantitative ICGA- and OCT-derived indices may serve as noninvasive biomarkers for evaluating choroidal remodeling and treatment response after PRP in diabetic retinopathy.

Indexed as

ChoroidDiabetic RetinopathyFluorescein AngiographyLaser CoagulationMultimodal ImagingRetinal VesselsTomography, Optical CoherenceAgedFemaleFollow-Up StudiesFundus OculiHumansMaleMiddle AgedRetrospective StudiesVisual AcuityChoroidal thicknessChoroidal vascular densityChoroidal vascularity indexChoroidal vascular remodelingEnhanced-depth imaging OCTFractal dimensionPanretinal photocoagulationUltra-widefield ICGA

Identifiers

PMID42065737
PMCPMC13635053

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.