Evidence map›Paper›PMID 42065720›Full record

ArticleCellular and molecular life sciences : CMLS2026

Sirtuin 7 ameliorates hypertensive intestinal injury by restoring epithelial barrier integrity and gut microbiota homeostasis.

Siyuan Wang, Minjie Wang, Xinyu Zhou, Kaixin Yan, Yufei Chen, Yihang Chen, Yaxuan Yao, Ying Dong, Jiuchang Zhong, Jing Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Siyuan WangHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, 8Th Gongtinanlu Rd, Chaoyang District, Beijing, China.
Minjie WangHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, 8Th Gongtinanlu Rd, Chaoyang District, Beijing, China.
Xinyu ZhouHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, 8Th Gongtinanlu Rd, Chaoyang District, Beijing, China.
Kaixin YanHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, 8Th Gongtinanlu Rd, Chaoyang District, Beijing, China.
Yufei ChenHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, 8Th Gongtinanlu Rd, Chaoyang District, Beijing, China.
Yihang ChenHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, 8Th Gongtinanlu Rd, Chaoyang District, Beijing, China.
Yaxuan YaoHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, 8Th Gongtinanlu Rd, Chaoyang District, Beijing, China.
Ying DongHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, 8Th Gongtinanlu Rd, Chaoyang District, Beijing, China.
Jiuchang Zhong *Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, 8Th Gongtinanlu Rd, Chaoyang District, Beijing, China. jczhong@sina.com.ORCID http://orcid.org/0000-0002-2315-3515
Jing Li *Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, 8Th Gongtinanlu Rd, Chaoyang District, Beijing, China. lijing11999@163.com.ORCID http://orcid.org/0000-0002-5102-4315

Funding

2025 Reform and Development Program of Beijing Institute of Respiratory Medicine Ggyfz202501National Natural Science Foundation of China 82570477
6 · The paper itself

Abstract

Hypertension is increasingly recognized as a contributor to intestinal barrier disruption and gut microbiota dysbiosis, thereby promoting systemic inflammation and end-organ damage. Sirtuin 7 (SIRT7), a nicotinamide adenine dinucleotide (NAD

Indexed as

Gastrointestinal MicrobiomeHypertensionIntestinal MucosaSirtuinsAnimalsHomeostasisIntestinal Barrier FunctionMaleRatsRats, Inbred SHRSIRT7 protein, ratSirtuinsGut microbiotaHypertensionIntestinal injurySirtuin 7

Identifiers

PMID42065720
PMCPMC13275981

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.