In one paragraphArticle in American journal of physiology. Gastrointestinal and liver physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
12 authors.
Brooke M BullardDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States.ORCID 0000-0003-0923-9950 Brandon N VanderVeenDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States.ORCID 0000-0002-4535-0544 Thomas D CardaciDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States.ORCID 0000-0002-4339-819X Sierra J McDonaldDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States.
Arianna V BastianDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States.ORCID 0009-0001-5886-8203 Nathaniel B WillisDepartment of Nutritional Sciences, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0003-1401-8204 Mingming XuDepartment of Chemistry and Biochemistry, College of Arts and Sciences, University of South Carolina, Columbia, South Carolina, United States.
Jie LiDepartment of Chemistry and Biochemistry, College of Arts and Sciences, University of South Carolina, Columbia, South Carolina, United States.
Joseph F PierreDepartment of Nutritional Sciences, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0002-4248-1290 Lorne J HofsethDepartment of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, South Carolina, United States.
Daping FanDepartment of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, United States.
E Angela MurphyDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States.ORCID 0000-0002-4803-5822 Funding
The Center for Clinical and Translational Research at the University of South Carolina (CLINTRUSC)P20GM155896 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI FRANCIS G SPINALE · 2024 to 2026
$9.5MTRAINING IN NUTRITIONT32DK007665 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI GUY E GROBLEWSKI, Chi- Liang Eric Yen · 1993 to 2026
$9.2MA Transdisciplinary Approach to Investigating Metabolic Dysregulation in Obese Parent and Child Dyads and Risk of Colorectal Cancer - admin supplementU01CA272977 · NCI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI JAMES R HEBERT, Lorne J Hofseth · 2022 to 2026
$4.7MUNC Integrated Translational Oncology Program (UNC-iTOP)T32CA244125 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WILLIAM Y. KIM, Jen Jen Yeh · 2019 to 2026
$3.9MHarnessing the Power of p53 with Panaxynol from American Ginseng to Suppress Colitis and Prevent Colon Cancer - admin suppR01CA246809 · NCI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI HOFSETH, LORNE J, MURPHY, ELIZABETH ANGELA · 2020 to 2024
$2.2MImpact of Obesity on Chemotherapy-Induced Cytotoxicity: Immune Cells and Skeletal MuscleR00CA276891 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Brandon VanderVeen · 2025 to 2026
$498kMicrobiome-Mitochondrial Interactions Driving Cancer-Induced Cachexia in the Obese StateF99CA294251 · NCI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI CARDACI, THOMAS · 2024 to 2025
$79kBenefits of panaxynol on gut resilience in colitisF31AT012589 · NCCIH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI BULLARD, BROOKE · 2024 to 2024
$38kHHS | NIH | National Cancer Institute (NCI) F99CA294251HHS | NIH | National Cancer Institute (NCI) R00CA27689HHS | NIH | National Cancer Institute (NCI) R01CA246809HHS | NIH | National Cancer Institute (NCI) T32CA244125HHS | NIH | National Cancer Institute (NCI) U01CA272977HHS | NIH | National Center for Complementary and Integrative Health (OAM) F31AT012589HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) T32DK007665HHS | NIH | National Institute of General Medical Sciences (NIGMS) P20GM155896NCCIH NIH HHS F31 AT012589NCI NIH HHS F99 CA294251NCI NIH HHS R00 CA276891NCI NIH HHS R01 CA246809NCI NIH HHS T32 CA244125NCI NIH HHS U01 CA272977NIDDK NIH HHS T32 DK007665NIGMS NIH HHS P20 GM155896
6 · The paper itselfAbstract
Chemotherapy-induced mucositis (CIM) is a debilitating side effect impacting as many as 90% of patients with cancer undergoing treatment. Patients receiving 5-fluorouracil (5FU), a first-line chemotherapeutic in colorectal cancer, experience significant gastrointestinal distress that perpetuates poor patient quality of life and reduces treatment tolerance, efficacy, and survival. Natural compounds have shown promise in improving CIM through their pleiotropic actions, including immune and mucosal regulation. We examined whether panaxynol, a bioactive compound isolated from American ginseng, can alleviate murine CIM symptomology and severity. Intestinal mucositis was induced in C57BL/6J male and female mice by 5 consecutive intraperitoneal injections of 5FU (35 mg/kg/day); PBS was used as the control. Vehicle or panaxynol (2.5 mg/kg/day) was administered via oral gavage every other day, starting on
Indexed as
ColonDiynesFatty AlcoholsFluorouracilIntestinal MucosaMucositisAnimalsDisease Models, AnimalFemaleGastrointestinal MicrobiomeMaleMiceMice, Inbred C57BLDiynesfalcarinolFatty AlcoholsFluorouracilamerican ginsengchemotherapyimmune profilemacrophagesmicrobiome
Identifiers
PMID42065376
PMCPMC13270280
What OpenQuestion holds
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