ArticleMedicine2026
Glymphatic system impairment in primary angle-closure glaucoma: A cross-sectional study of disease severity.
Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The glymphatic system plays a critical role in brain waste clearance and has been implicated in neurodegenerative diseases. Primary angle-closure glaucoma (PACG) is increasingly recognized as a neurodegenerative disorder extending beyond the eye. This study aimed to investigate glymphatic system function in patients with PACG using diffusion tensor imaging analysis along the perivascular space (DTI-ALPS). This cross-sectional study included patients with PACG and age- and sex-matched healthy controls. All participants underwent magnetic resonance imaging, including diffusion tensor imaging. The DTI-ALPS index was calculated to assess glymphatic function. Group differences and correlations with disease severity were analyzed. Patients with PACG showed a significantly lower whole-brain DTI-ALPS index compared with healthy controls (1.50 ± 0.14 vs 1.60 ± 0.15, P = .030; Cohen d = 0.63). Lower DTI-ALPS values were significantly correlated with worse visual field mean deviation and thinner retinal nerve fiber layer thickness (P < .05). Glymphatic system function appears to be impaired in PACG and is associated with disease severity. These findings provide further evidence supporting the concept of glaucoma as a neurodegenerative disease involving the central nervous system.
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