ReviewAngewandte Chemie (International ed. in English)2026
Merging Biocatalysis and Chemocatalysis in Flow: State-of-the-Art and Future Directions for Sustainable Synthesis.
Review in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The growing demand for complex molecules continues to drive innovation in organic synthesis, yet challenges in sustainability, selectivity, scalability, and harsh reaction conditions persist. Enzymes offer exquisite chemo-, regio-, and stereoselectivity under mild conditions, while chemocatalysis provides robust and versatile reactivity. However, integrating these approaches into streamlined processes remains difficult due to incompatible conditions and operational constraints. Continuous flow chemistry offers a promising solution by enabling the efficient combination of biocatalysis and chemocatalysis, while improving atom economy, reaction control, scalability, and energy efficiency. This review highlights key advances up to 2025 in merging enzymatic and chemical steps into streamlined continuous flow cascades. It analyzes examples involving various enzyme classes-hydrolases, oxidoreductases, lyases, transferases, and isomerases-used alongside chemical catalysts. Major challenges such as enzyme immobilization, catalyst leaching, and reactor clogging are discussed, along with innovative solutions. The review also discusses how advanced enzyme engineering and immobilization strategies enhance biocatalyst activity, stability, and compatibility with chemical steps. By outlining recent progress and future directions, this review emphasizes how the integration of biocatalysis, chemocatalysis, and flow chemistry can foster more sustainable and efficient synthetic methodologies, particularly relevant to the pharmaceutical and fine chemical industries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.