Evidence map›Paper›PMID 42065097›Full record

ArticleClinical & translational immunology2026

High-dimensional multiomics reveals perturbations to IL-6/IL-6R axis and RUNX3 in CD4

Jennifer R Habel, Thi H O Nguyen, Natasha de Alwis, E Kaitlynn Allen, Shihan Li, Morgan J Skinner, Jennifer A Juno, Stephen J Kent, Katherine Bond, Deborah A Williamson and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical & translational immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Jennifer R HabelDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity Melbourne VIC Australia.
Thi H O NguyenDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity Melbourne VIC Australia.
Natasha de AlwisThe Department of Obstetrics, Gynaecology and Newborn Health University of Melbourne Heidelberg VIC Australia.
E Kaitlynn AllenDepartment of Immunology St. Jude Children's Research Hospital Memphis TN USA.
Shihan LiComputational Sciences Initiative, Department of Immunology and Microbiology University of Melbourne at the Peter Doherty Institute for Infection and Immunity Melbourne VIC Australia.
Morgan J SkinnerDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity Melbourne VIC Australia.
Jennifer A JunoDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity Melbourne VIC Australia.
Stephen J KentDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity Melbourne VIC Australia.ORCID https://orcid.org/0000-0002-8539-4891
Katherine BondVictorian Infectious Diseases Reference Laboratory, at the Peter Doherty Institute for Infection and Immunity Melbourne VIC Australia.
Deborah A WilliamsonVictorian Infectious Diseases Reference Laboratory, at the Peter Doherty Institute for Infection and Immunity Melbourne VIC Australia.
Martha LappasThe Department of Obstetrics, Gynaecology and Newborn Health University of Melbourne Heidelberg VIC Australia.
Natalie J HannanThe Department of Obstetrics, Gynaecology and Newborn Health University of Melbourne Heidelberg VIC Australia.
Susan WalkerThe Department of Obstetrics, Gynaecology and Newborn Health University of Melbourne Heidelberg VIC Australia.
Jan SchroederComputational Sciences Initiative, Department of Immunology and Microbiology University of Melbourne at the Peter Doherty Institute for Infection and Immunity Melbourne VIC Australia.
Jeremy Chase CrawfordDepartment of Host-Microbe Interactions St. Jude Children's Research Hospital Memphis TN USA.
Paul G ThomasImmunology and Vaccine Development Program, Vaccine and Infectious Disease Division Fred Hutchinson Cancer Center Seattle WA USA.
Katherine KedzierskaDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity Melbourne VIC Australia.
Louise C RowntreeDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity Melbourne VIC Australia.

Funding

Household Respiratory Virus SARS-CoV-2 Transmission and Immunity Sub-Study (HRTS)U01AI144616 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI GORDON, AUBREE L, THOMAS, PAUL G. · 2019 to 2025
$43.7M
NIAID NIH HHS U01 AI144616
6 · The paper itself

Abstract

Objectives: CD4 Methods: CD4 Results: Surface protein screening identified changes to ILT4/CD85d, CD9, IFN-γ receptor β-chain, CX3CR1 and CCR5 in the pregnant blood and decidual CD4 Conclusions: Our findings demonstrate altered molecular expression in CD4

Indexed as

CD4+ T cellhumanIL‐6Rpregnancy

Identifiers

PMID42065097
PMCPMC13125720

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.