Evidence map›Paper›PMID 42065074›Full record

ArticleOncology research2026

Targeting Oncogenic lncRNA KRT7-AS to Induce Ferroptosis Suppresses Ovarian Cancer Progression.

Yan Zhu, Bin Guan, Wencai Guan, Jihong Zhang, Shiyu Wang, Jimin Shi, Wei Fan, Qi Lu, Lingyun Zhang, Guoxiong Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yan ZhuResearch Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai, China.
Bin GuanResearch Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai, China.
Wencai GuanResearch Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai, China.
Jihong ZhangResearch Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai, China.
Shiyu WangResearch Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai, China.
Jimin ShiResearch Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai, China.
Wei FanResearch Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai, China.
Qi LuDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Lingyun ZhangDepartment of Medical Oncology, Shanghai Geriatric Medical Center, Shanghai, China.
Guoxiong XuResearch Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ovarian cancer poses the greatest threat to survival among gynecologic cancers in women. Long non-coding RNAs (lncRNAs) have emerged as critical regulators in oncogenesis. The current study aimed to elucidate the function and regulatory mechanism of lncRNA KRT7-AS in ovarian cancer. Methods: The clinical significance of KRT7-AS was evaluated through bioinformatics analysis of data from public repositories. KRT7-AS expression was examined by RT-qPCR and fluorescence Results: Patients exhibiting high KRT7-AS expression had a significantly lower survival rate. Functional assays demonstrated that KRT7-AS overexpression enhanced tumorigenic behaviors, including cell proliferation, invasion, and metastasis, whereas its knockdown suppressed these malignant phenotypes. KRT7-AS depletion induced ferroptosis, as indicated by increased MMP and ROS levels, and the accumulation of lipid peroxidation and Fe Conclusions: These findings suggest that KRT7-AS has potential as a diagnostic biomarker for ovarian cancer. Targeting KRT7-AS to induce ferroptosis may represent a promising therapeutic strategy for suppressing ovarian cancer progression.

Indexed as

FerroptosisKeratin-7Ovarian NeoplasmsRNA, Long NoncodingAnimalsApoptosisCell Line, TumorCell MovementCell ProliferationDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansMiceReactive Oxygen SpeciesXenograft Model Antitumor AssaysKeratin-7Reactive Oxygen SpeciesRNA, Long NoncodingBiomarkerferroptosisnon-coding RNAoncogenesistumor suppression

Identifiers

PMID42065074
PMCPMC13126565

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.