Evidence map›Paper›PMID 42065071›Full record

ReviewOncology research2026

The Role of Immunotherapy in Resectable Non-Small Cell Lung Cancer.

Francesco Petrella, Andrea Cara, Enrico Mario Cassina, Lidia Libretti, Emanuele Pirondini, Federico Raveglia, Maria Chiara Sibilia, Antonio Tuoro

Abstract readReview
In one paragraph

Review in Oncology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Francesco PetrellaDepartment of Thoracic Surgery, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Andrea CaraDepartment of Thoracic Surgery, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Enrico Mario CassinaDepartment of Thoracic Surgery, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Lidia LibrettiDepartment of Thoracic Surgery, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Emanuele PirondiniDepartment of Thoracic Surgery, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Federico RavegliaDepartment of Thoracic Surgery, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Maria Chiara SibiliaDepartment of Thoracic Surgery, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Antonio TuoroDepartment of Thoracic Surgery, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The advent of immune checkpoint inhibitors (ICIs) targeting PD-1, PD-L1, and CTLA-4 has transformed the therapeutic landscape of advanced non-small cell lung cancer (NSCLC), and recent clinical trials have extended their application to resectable disease. Multiple randomized phase III trials have demonstrated that neoadjuvant and adjuvant immunotherapy, particularly when combined with platinum-based chemotherapy, significantly improves pathological complete response (pCR), major pathological response (MPR), event-free survival (EFS), disease-free survival (DFS), and overall survival (OS) compared to chemotherapy alone. Several key questions remain unresolved-including whether preoperative or postoperative immunotherapy yields superior outcomes, whether adjuvant therapy provides additional benefit after neoadjuvant immune checkpoint inhibitors plus chemotherapy (ICI-CT), and how best to identify the patients most likely to benefit from each strategy. This review will critically examine the current evidence, clinical trial landscape, and future directions for immunotherapy in resectable NSCLC.

Indexed as

Carcinoma, Non-Small-Cell LungImmune Checkpoint InhibitorsImmunotherapyLung NeoplasmsChemotherapy, AdjuvantHumansNeoadjuvant TherapyImmune Checkpoint Inhibitorsimmune checkpoint inhibitorsimmunotherapylung resectionNon-small cell lung cancerpathological response

Identifiers

PMID42065071
PMCPMC13126603

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.