ArticleFrontiers in neurology
Efficacy of intravenous immunoglobulin in children with drug-resistant epilepsy.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Purpose: Inflammation may contribute to drug-resistant epilepsy (DRE) in children and immunomodulatory therapies, including intravenous immunoglobulin (IVIG), have been described to reduce seizure burden. This retrospective study assesses the effect of IVIG on seizures in a tertiary epilepsy center. Methods: We performed a retrospective chart review of children with DRE using our Pediatric Epilepsy Outcome-Informatics database, which contains standardized information on 3,650 pediatric epilepsy patients collected at the point of care. Inclusion criteria were refractory seizures, regular follow-up and treatment with IVIG for at least 1 year. Patients with autoimmune encephalitis were excluded from the analysis. Sex, etiology, epilepsy syndromes, seizure types, antiseizure medications (ASM), adverse effects, and seizure frequency scores prior, 3 months post-, and 1-year post-IVIG were collected and statistically compared. Results: Sixty patients aged 2-18 years (mean ± SD, 11.8 ± 4.13) were included. Patients exhibited focal (38.3%, Conclusion: Long-term use of IVIG in pediatric patients can be an effective treatment for refractory seizures, even if exact mechanisms remain unclear.
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