Evidence map›Paper›PMID 42064962›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Meta-analysis of Cannabis Use Identifies Shared Genetic Loci with Sleep and Circadian Rhythms.

Jesse Valliere, Satu Strausz, Cynthia Tchio, Oona Shigeno Risse-Adams, Nasa Sinnott-Armstrong, Hanna M Ollila, Richa Saxena

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jesse ValliereCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Satu StrauszCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Cynthia TchioCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-2516-010X
Oona Shigeno Risse-AdamsHerbold Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0002-4350-663X
Nasa Sinnott-ArmstrongHerbold Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0003-4490-0601
Hanna M OllilaCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Richa SaxenaCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-2233-1065

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cannabis use is an increasingly common therapeutic for a variety of chronic diseases. In addition, people with sleep problems may self-medicate using cannabis products. However, genetic architecture of cannabis use and its shared genetic predispositions with sleep traits has not been systematically examined. We performed a meta-analysis of cannabis use within the All of Us and UK Biobank cohorts, consisting of 152,807 cases and 220,272 controls. Our meta-analysis identified 39 independent loci, including the previously reported

Identifiers

PMID42064962
PMCPMC13127527

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.