Evidence map›Paper›PMID 42064938›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Loneliness as a Pathway Linking Hearing Decline to Cognitive Aging: Longitudinal and Genetic Evidence.

Shuai Yang, Matthew D Grilli, Robyn E Wootton, Margot P van de Weijer, Jorien L Treur, Yann C Klimentidis, David A Sbarra

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shuai YangDepartment of Epidemiology and Biostatistics, Mel & Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.ORCID 0009-0004-9547-0837
Matthew D GrilliDepartment of Psychology, University of Arizona, Tucson, AZ, USA.
Robyn E WoottonMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Margot P van de WeijerDepartment of Psychiatry, Amsterdam UMC location, University of Amsterdam, Amsterdam, The Netherlands.
Jorien L TreurDepartment of Psychiatry, Amsterdam UMC location, University of Amsterdam, Amsterdam, The Netherlands.
Yann C KlimentidisDepartment of Epidemiology and Biostatistics, Mel & Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.
David A SbarraDepartment of Psychology, University of Arizona, Tucson, AZ, USA.

Funding

Genetically Informed Studies of Social Connectedness and HealthR01AG078361 · NIA · UNIVERSITY OF ARIZONA · PI DAVID A SBARRA · 2022 to 2026
$5.6M
NIA NIH HHS R01 AG078361
6 · The paper itself

Abstract

Age-related hearing loss is linked to loneliness and poorer cognitive health, but it remains unclear whether loneliness helps explain associations between hearing difficulties and cognitive performance or dementia, and whether these patterns reflect causal pathways or shared underlying liability. In this preregistered study, we triangulated analyses across multiple data sources spanning approximately 18 years of observational data with 8 sources of molecular genetic information to examine whether loneliness helps explain the association between hearing difficulty and cognitive performance, Alzheimer's disease dementia, and all-cause dementia, and whether hearing-aid use may buffer this association. In longitudinal parallel-process latent growth curve models (

Indexed as

cognitive agingcolocalizationhearing aidshearing losslonelinessMendelian randomizationneuroticismSHARE

Identifiers

PMID42064938
PMCPMC13127512

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.