Evidence map›Paper›PMID 42064878›Full record

ArticleJournal of oral microbiology2026

Treatment of periodontal biofilms via nitric oxide-augmented phototherapy.

Courtney R Johnson, Tsian D Ramrattan, Casimir J Schaefer, Rajnish Kumar, Simon J Reinhard, Shannon M Wallet, Mark H Schoenfisch

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of oral microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Courtney R JohnsonDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID https://orcid.org/0009-0008-1885-860X
Tsian D RamrattanDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Casimir J SchaeferDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Rajnish KumarDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Simon J ReinhardDepartment of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL, USA.
Shannon M WalletDepartment of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL, USA.
Mark H SchoenfischDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID https://orcid.org/0000-0002-2212-0658

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: This study investigated the antibacterial action of photo-liberated nitric oxide (NO) from primary and tertiary Materials and methods: The antibacterial and antibiofilm efficacy of photo-liberated NO release from 1° RSNO-MSNs and 3° RSNO-MSNs was evaluated as a function of wavelength (405 and 455 nm), irradiance (400-1000 mW cm Results: The addition of photo-initiated NO release with aBLT significantly improved antibiofilm activity, with irradiation of 405 nm at 1000 mW cm Conclusions: The in vitro and ex vivo results demonstrate, for the first time, the utility of a dual-action aBLT and NO-releasing system for treating periodontal pathogens and biofilms.

Indexed as

antibacterial blue light therapylight-mediated releasemesoporous silica nanoparticlesNitric oxideperiodontal diseaseS-nitrosothiolssubgingival infection

Identifiers

PMID42064878
PMCPMC13126946

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.