ArticleOpen life sciences2026
Donkey serum albumin improves cyclophosphamide-induced anemia in mice.
Article in Open life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cyclophosphamide (CP) is commonly used in cancer chemotherapy and the treatment of autoimmune diseases. In clinical applications, it exhibits the side effect of progressive anemia. Donkey serum albumin (DSA) is the most abundant protein component in Asini Corii Colla (ACC). This experiment aims to investigate the alleviating effect of donkey serum albumin on CP-induced anemia. 60 mice were randomly divided into six groups: normal control group (NC), model control group (MC), positive control group (PC), low-dose DSA (DSA-L, 75 mg/kg/d), medium-dose DSA (DSA-M, 150 mg/kg/d), and high-dose DSA (DSA-H, 300 mg/kg/d), with 10 mice in each group. An anemia model was established by intraperitoneal injection of CP. The treatment continued for 21 days. Afterward, the mice were euthanized, and histopathological examinations of bone marrow and spleen tissues were conducted. Organ indices, the number of bone marrow nucleated cells, and the levels of Erythropoietin (EPO), Thrombopoietin (TPO), and Vascular Endothelial Growth Factor (VEGF) in mouse serum and bone marrow supernatant were measured using ELISA. The model group exhibited significantly lower thymus index, White Blood Cell count (WBC), Red Blood Cell count (RBC),Hemoglobin (HGB), Platelet count (PLT), and bone marrow nucleated cell count (
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