Evidence map›Paper›PMID 42064819›Full record

ArticleFrontiers in pharmacology2026

Protective role of miR-712-3p in heatstroke-induced brain injury: involvement of neuronal lysosomal function and association with astrocytic exosome-enriched preparations.

Yahong Chen, Jie Zhu, Shuhuan Li, Peishan Liang, Yiqiong Zhang, Guangli Ren

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yahong Chen *Department of Pediatric, General Hospital of Southern Theater Command, Guangzhou, China.
Jie Zhu *Department of Pediatric, General Hospital of Southern Theater Command, Guangzhou, China.
Shuhuan Li *Department of Pediatric, The Eighth Affiliated Hospital of Southern Medical University (The First People's Hospital of Shunde Foshan), Foshan, China.
Peishan LiangDepartment of Pediatric, General Hospital of Southern Theater Command, Guangzhou, China.
Yiqiong ZhangDepartment of Pediatric, General Hospital of Southern Theater Command, Guangzhou, China.
Guangli RenDepartment of Pediatric, General Hospital of Southern Theater Command, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While glia-derived exosomes have been extensively studied in heatstroke induced brain injury, the role of exosomal microRNAs (miRNAs) secreted by astrocyte remains underexplored. In this study, the viability of C8-D1A cells decreased after heat stress, apoptosis rate and the expression levels of proinflammatory cytokines such as TNF-α, IL-6, IL-1α and IL-1β increased to different degrees. The extracellular vesicles obtained by ultracentrifugation were identified

Indexed as

astrocytebrain injuryexosome-enriched preparationsheatstrokemiR-712-3p

Identifiers

PMID42064819
PMCPMC13125176

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.