ArticleFrontiers in pharmacology2026
PHGDH-mediated serine synthesis reduces oligodendrocyte death by sustaining GSH and NADPH levels after brain ischemia.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: White matter is vulnerable to early ischemic injury. The susceptibility of oligodendrocytes to ischemic damage can lead to demyelination, axonal degeneration, and neurological deficits, making them a key focus for understanding and developing therapies for stroke-related brain injury. In this study, we aimed to investigate how cell metabolism contributes to oligodendrocyte survival and white matter integrity maintenance following ischemia. Methods: NCT-503 was injected after inducing transient middle cerebral artery occlusion. After reperfusion, brain infarct volume and neurobehavioral deficits and behaviour performance were assessed. Immunofluorescence staining was performed to evaluate oligodendrocytes death. Cell viability was measured using the CCK8 assay. Flow cytometry analysis was conducted to examine reactive oxygen species (ROS) levels. Results: Conclusion: This study reveals the role of PHGDH-mediated
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