ArticleFrontiers in pharmacology2026
Neuroprotective effects of rutin, sodium selenite, and rutin-conjugated selenium nanoparticles in a social isolation model.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Metabolic and redox modulation by 2-deoxy-D-glucose and sodium selenite protects against pentylenetetrazole-kindled seizures, neuroinflammation and cognitive dysfunction.Metabolic brain disease · 2026Article
- Targeting mitochondrial dysfunction and apoptosis in 5-fluorouracil-induced cardiotoxicity using kaempferol-mediated selenium nanoparticles.Scientific reports · 2026Article
- Rutin-Functionalized Selenium Nanoparticles Attenuate Cisplatin-Induced Cardiohepatic Injury in Rats: Modulation of ER Stress-Related Gene Expression and Mitochondrial Apoptotic Markers.International journal of molecular sciences · 2026Article
- Article
- Ouabain Relieves Sleep Deprivation-Induced Anxiety-Like Behavior in Mice by Suppressing Hippocampal Neuroinflammation and Oxidative Stress.Brain and behavior · 2026Article
Corrections and comments
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Authors and funding
13 authors.
Funding
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Abstract
Background: Social isolation (SI) is a long-standing experimental paradigm that models schizophrenia-like behavioural and neurobiological changes caused by the action of oxidative stress, neuroinflammation, apoptosis, and neurotransmitter imbalance. The scope of this paper was to comparatively assess the effectiveness of rutin, sodium selenite (Na Methods: In silico analysis of Rutin activity including Results: SI induction produced significant behavioral, biochemical, neurochemical, and structural impairments compared with controls ( Conclusion: Rutin and sodium selenite provided significantly protective effects across behavioral, biochemical, and neurochemical parameters. Among all treatments, RUT-SeNPs produced markedly attenuated, restoring nearly all measured markers including redox balance, cytokines, apoptosis regulators, neurotransmitters, BDNF/GFAP levels, and cortical histology to values comparable to controls.
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Registered trials
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