Evidence map›Paper›PMID 42064791›Full record

ArticleFrontiers in pharmacology2026

Linlin Wang, Yu Miao, Hailong Wang, Hamulati Hasimu, Tengfei Ji, Hua Huang, Guanhua Du, Haji Akber Aisa, Xuelei Xin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Linlin WangState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, and the Key Laboratory of Chemistry of Plant Resources in Arid Regions Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China.
Yu MiaoState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, and the Key Laboratory of Chemistry of Plant Resources in Arid Regions Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China.
Hailong WangXinjiang Medical University, Urumqi, China.
Hamulati HasimuXinjiang Key Laboratory of Uygur Medicine, Xinjiang Institute of Materia Medica, Urumqi, China.
Tengfei JiState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College and Beijing Key Laboratory of Drug Target and Screening Research, Beijing, China.
Hua HuangXinjiang Key Laboratory of Uygur Medicine, Xinjiang Institute of Materia Medica, Urumqi, China.
Guanhua DuState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College and Beijing Key Laboratory of Drug Target and Screening Research, Beijing, China.
Haji Akber AisaState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, and the Key Laboratory of Chemistry of Plant Resources in Arid Regions Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China.
Xuelei XinState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, and the Key Laboratory of Chemistry of Plant Resources in Arid Regions Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Metabolic dysfunction-associated steatohepatitis (MASH) is the most prevalent chronic liver disease worldwide; however, few effective therapeutic options are available for MASH. Aim of the study: The objective of this research was to assess the protective effects and further mechanisms of Methods: The protective effects of AS were evaluated both Results: AS reduced the blood lipid indices and inflammatory levels in the MASH mouse model and decreased lipid droplet accumulation in FFA-induced HepG2 cells. Transcriptomic and metabolomic analyses indicated that AS regulates 30 dysregulated genes (e.g., Conclusion: This study first elucidates the mechanism through which AS ameliorates MASH through integrated multi-omics analysis, providing experimental evidence for further development of natural therapeutic agents.

Indexed as

AGE–RAGE signaling pathwayArtemisia scopariaferroptosisJAK–STAT signaling pathwaymetabolic dysfunction-associated steatohepatitismetabolomicstranscriptomics

Identifiers

PMID42064791
PMCPMC13125038

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.