Evidence map›Paper›PMID 42064774›Full record

ArticleFrontiers in endocrinology2026

Cadmium chloride and erectile dysfunction: integrative evidence from network toxicology, Mendelian randomization, and

Yuqi Li, Qilong Wu, Chunyang Meng, Zhiyu Liu, Tao Zhou, Xinyao Zhu, Jihong Wang, Qingfu Deng, Yang Zeng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuqi LiDepartment of Urology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Qilong WuDepartment of Urology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Chunyang MengDepartment of Urology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Zhiyu LiuDepartment of Urology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Tao ZhouDepartment of Urology, Santai Hospital Affiliated to North Sichuan Medical College, Mianyang, Sichuan, China.
Xinyao ZhuDepartment of Urology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Jihong WangDepartment of Oncology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Qingfu DengDepartment of Urology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Yang ZengDepartment of Urology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In recent years, heavy metal exposure has been increasingly implicated in the onset and progression of various diseases. However, the relationship between heavy metal exposure and male erectile function remains insufficiently understood. This study aimed to investigate the association between cadmium chloride (CdCl Methods: An integrated analytical framework was established to elucidate the potential link between cadmium chloride and ED. Key cadmium-ED related genes were first identified through comprehensive analyses using multiple databases, including PubChem, TargetNet, GeneCards, and STRING. Subsequently, Mendelian randomization (MR) analysis was conducted to assess the causal relationship between cadmium associated genes and ED. Finally, Results: Network toxicology analysis identified estrogen receptor 2 ( Conclusion: CdCl

Indexed as

Cadmium ChlorideEnvironmental PollutantsErectile DysfunctionEstrogen Receptor betaCell SurvivalEnvironmental ExposureGene Expression RegulationHumansHuman Umbilical Vein Endothelial CellsMaleMendelian Randomization AnalysisProtein Interaction MappingProtein Interaction MapsToxicity Tests, AcuteCadmium ChlorideEnvironmental PollutantsESR2 protein, humanEstrogen Receptor betacadmium chlorideendocrine disruptingerectile dysfunctionMendelian randomization analysisnetwork toxicology

Identifiers

PMID42064774
PMCPMC13124623

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.