Evidence map›Paper›PMID 42064760›Full record

ReviewFrontiers in endocrinology2026

Pancreatic islet cell calcium ion imaging at single-cell resolution: functional identification of first-responder, highly connected ("hub"), and leader beta-cells.

Luis Fernando Delgadillo-Silva, Giada Ostinelli, Audrey Provencher-Girard, Shadai Salazar, Rana Melhem, Guy A Rutter

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Luis Fernando Delgadillo-SilvaCardiometabolic Axis, University of Montreal Hospital Research Centre (CR-CHUM) and Department of Medicine, University of Montreal, Montreal, QC, Canada.
Giada OstinelliCardiometabolic Axis, University of Montreal Hospital Research Centre (CR-CHUM) and Department of Medicine, University of Montreal, Montreal, QC, Canada.
Audrey Provencher-GirardCardiometabolic Axis, University of Montreal Hospital Research Centre (CR-CHUM) and Department of Medicine, University of Montreal, Montreal, QC, Canada.
Shadai SalazarCardiometabolic Axis, University of Montreal Hospital Research Centre (CR-CHUM) and Department of Medicine, University of Montreal, Montreal, QC, Canada.
Rana MelhemCardiometabolic Axis, University of Montreal Hospital Research Centre (CR-CHUM) and Department of Medicine, University of Montreal, Montreal, QC, Canada.
Guy A RutterCardiometabolic Axis, University of Montreal Hospital Research Centre (CR-CHUM) and Department of Medicine, University of Montreal, Montreal, QC, Canada.

Funding

Control of insulin secretion by mitochondrial fusionR01DK135268 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Brett A Kaufman, Scott Soleimanpour · 2023 to 2026
$2.4M
NIDDK NIH HHS R01 DK135268Wellcome Trust
6 · The paper itself

Abstract

Increases in cytoplasmic free Ca

Indexed as

CalciumCalcium SignalingInsulin-Secreting CellsIslets of LangerhansSingle-Cell AnalysisAnimalsInsulinInsulin SecretionMiceCalciumInsulinbeta-cellsCa2+connectivityfirst-respondershubsisletsleaders

Identifiers

PMID42064760
PMCPMC13124488

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.