ArticleFrontiers in endocrinology2026
Application of multimodal ultrasound in the biomechanical evaluation of carotid intima-media thickness in type 2 diabetes mellitus: a focus on subclinical vascular changes.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Biomarker value of plasma endothelial microvesicle-derived circRNA 0006222 in vascular ageing and carotid atherosclerosis.Frontiers in neuroscience · 2026Article
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5 authors.
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Abstract
Objective: To assess multimodal ultrasound technology in the biomechanical assessment of carotid intima-media thickness (cIMT) in patients with type 2 diabetes mellitus (T2DM), specifically focusing on those with increased cIMT but without atherosclerotic plaques or significant stenosis. Methods: In this exploratory cross-sectional study, 65 T2DM patients (thickened vs. normal cIMT) and 27 controls were examined using color Doppler ultrasound flow imaging (CDFI), ultrasound vector flow imaging (V-Flow), and ultra-fast pulse wave velocity (UF-PWV). Measurements included peak systolic velocity (PSV), end-diastolic velocity (EDV), pulsatility index (PI), resistance index (RI), wall shear stress (WSS), pulse wave velocity at the beginning of systole (PWV-BS), and pulse wave velocity at the end of systole (PWV-ES). Differences across groups and independent factors associated with cIMT were analyzed via correlation and multivariable linear regression. Results: The T2DM group exhibited higher HbA1c levels than the control group ( Conclusion: Preliminary findings suggest V-Flow and UF-PWV imaging may detect biomechanical alterations in T2DM patients. While these techniques may offer insights into subclinical vascular remodeling prior to plaque formation, this cross-sectional study should be cautiously interpreted as hypothesis-generating.
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