Evidence map›Paper›PMID 42064729›Full record

ArticleJournal of nucleic acids2026

A Biochemical Analysis of LINC00896 RNA in Cortex Neuronal Cells and Its Possible Connection to the Development of Autism.

Rachel A Hellmann Whitaker, Joshua J Storey, Isabella Vannavong, Robert S Mangiamele, Micalyn A Trihus, Donovan D Floyd, Trevor Rohder, Dylan L Cleveland, Andrew Rizea

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rachel A Hellmann WhitakerMedical School, University of Minnesota, Minneapolis, Minnesota, USA, umn.edu.ORCID https://orcid.org/0000-0002-9335-8647
Joshua J StoreySchool of Pharmacy, North Dakota State University, Fargo, North Dakota, USA, ndsu.edu.
Isabella VannavongDepartment of Chemistry, Bemidji State University, Bemidji, Minnesota, USA.
Robert S MangiameleDepartment of Chemistry, Bemidji State University, Bemidji, Minnesota, USA.
Micalyn A TrihusDepartment of Chemistry, Bemidji State University, Bemidji, Minnesota, USA.
Donovan D FloydDepartment of Chemistry, Bemidji State University, Bemidji, Minnesota, USA.
Trevor RohderDepartment of Chemistry, Bemidji State University, Bemidji, Minnesota, USA.
Dylan L ClevelandDepartment of Chemistry, Bemidji State University, Bemidji, Minnesota, USA.
Andrew RizeaDepartment of Chemistry, Bemidji State University, Bemidji, Minnesota, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism spectrum disorder is a complex neurological and developmental disorder that is characterized by altered brain structures and interconnectivity, which results in a vast array of psychosocial and physiological irregularities. This is due to the complex genetic topography of autism and to the intersectionality of genetic and environmental factors that contribute to the development of this disorder. To better understand the genetic factors that cause autism, the gene linc00896, which encodes a long noncoding intergenic RNA, was biochemically and biologically analyzed primarily through circular dichroism, liquid chromatography, and mass spectrometry. From this analysis, it was determined that LINC00896 RNA has a vast interactome and that through this interactome, LINC00896 RNA influences numerous cellular processes that contribute to the symptoms of autistic patients. Additionally, the structural analysis of LINC00896 RNA indicated stable but flexible secondary and tertiary structures that support the numerous binding interactions identified in the interactome. Through these empirical findings, the linc00896 gene was identified as being an important genetic factor that contributes to the development of autism.

Indexed as

autism spectrum disordergenetic risk factorslong noncoding RNAtranscriptome

Identifiers

PMID42064729
PMCPMC13127100

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.