Evidence map›Paper›PMID 42064726›Full record

ArticleJournal of inflammation research2026

Maiara Piva, Marília F Manchope, Fernanda Barbosa-Costa, Beatriz H S Bianchini, Ketlem C Andrade, Letícia Coelho Silva, Cássia Calixto-Campos, Fernanda S Rasquel-Oliveira, Victor Fattori, Ana Carla Zarpelon-Schutz and 4 more

Abstract read
In one paragraph

Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Maiara PivaDepartment of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, Paraná, Brazil.ORCID 0000-0003-4099-3492
Marília F ManchopeDepartment of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, Paraná, Brazil.
Fernanda Barbosa-CostaDepartment of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, Paraná, Brazil.ORCID 0009-0009-2969-2788
Beatriz H S BianchiniDepartment of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, Paraná, Brazil.
Ketlem C AndradeDepartment of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, Paraná, Brazil.
Letícia Coelho SilvaDepartment of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, Paraná, Brazil.
Cássia Calixto-CamposDepartment of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, Paraná, Brazil.
Fernanda S Rasquel-OliveiraDepartment of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, Paraná, Brazil.
Victor FattoriDepartment of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, Paraná, Brazil.
Ana Carla Zarpelon-SchutzDepartment of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, Paraná, Brazil.
Doumit Camilios-NetoDepartment of Biochemistry and Biotechnology, Londrina State University, Londrina, Paraná, Brazil.ORCID 0000-0002-1986-658X
Sergio M BorghiDepartment of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, Paraná, Brazil.ORCID 0000-0002-6978-7505
Rubia CasagrandeDepartment of Pharmaceutical Sciences, Londrina State University, Londrina, Paraná, Brazil.
Waldiceu A VerriDepartment of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, Paraná, Brazil.ORCID 0000-0003-2756-9283

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Potassium superoxide (KO Methods: Overt pain-like behavior, mechanical hyperalgesia, edema, leukocyte recruitment, oxidative stress markers, cytokine dosage by enzyme-linked immunosorbent assay (ELISA), nuclear factor kappa B (NF-κB) phosphorylation by Western blotting, mRNA expression by reverse transcription quantitative polymerase chain reaction (RT-qPCR), and neuronal activity by calcium levels were assessed. TC was administered orally 30 min before stimulation with KO Results: TC inhibited abdominal contortion, mechanical hyperalgesia, paw edema, and myeloperoxidase activity (an indirect marker of macrophage/neutrophil recruitment). TC induced antioxidant activity (assessed by ferric reducing ability and free radical scavenging), while reducing superoxide anion production and lipid peroxidation, at least in part, by upregulating Conclusion: These results demonstrate that the in vivo anti-inflammatory and analgesic activities of TC involve neuronal and non-neuronal mechanisms, and that non-antioxidant flavonoids are still biologically active.

Indexed as

analgesicflavonoidsnociceptionpotassium superoxideTRPA1TRPV1

Identifiers

PMID42064726
PMCPMC13127440

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.