ArticleChemical & biomedical imaging2026
Donor Modulation of Strong Near-Infrared Lipid-Droplet Probes for in Vivo Diagnosis of Nonalcoholic Fatty Liver Disease.
Article in Chemical & biomedical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- A dual-responsive fluorescent probe for imaging viscosity and polarity in nonalcoholic fatty liver disease.Smart molecules : open access · 2026Article
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9 authors.
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Abstract
Lipid droplet accumulation is a pathological hallmark of nonalcoholic fatty liver disease (NAFLD); however, the utility of current lipid droplet-targeted fluorescent probes for in vivo diagnosis is hindered by shallow tissue penetration and strong background autofluorescence. To overcome these challenges, here, we report three donor-acceptor-acceptor solvatochromic probes (CTBT-ANPy, PTBT-ANPy, and MOPTBT-ANPy) with tunable electron-donating groups, enabling near-infrared (NIR) imaging of lipid droplets and in vivo NAFLD diagnosis. Owing to multiple intramolecular interactions and restriction of twisted intramolecular charge transfer, these probes exhibit intense NIR emissions (up to 709 nm, quantum yield of 34.2%) in low-polarity media. These lipophilic probes display high lipid-droplet specificity with bright light-up signals and wash-free capacity. With the aid of NIR-emissive MOPTBT-ANPy, in vivo high-contrast fluorescent discrimination of NAFLD in a mouse model was successfully achieved. This study underscores the potential of high-performance NIR probes for noninvasive accurate NAFLD diagnosis and monitoring.
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