Evidence map›Paper›PMID 42064611›Full record

ArticleChemical & biomedical imaging2026

Novel "C-Clamp" Design of Highly Selective Small-Molecule Sensors for Kinase Proteins.

Shaista Ahmad, Aleksandr A Barashkin, Haniyeh Jadidi, Alan Calderon, Harouna Amadou, Adam B Ornberg, Evgueni E Nesterov, Irina V Nesterova

Abstract read
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In one paragraph

Article in Chemical & biomedical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shaista AhmadDepartment of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois 60115, United States.
Aleksandr A BarashkinDepartment of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois 60115, United States.
Haniyeh JadidiDepartment of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois 60115, United States.
Alan CalderonDepartment of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois 60115, United States.
Harouna AmadouDepartment of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois 60115, United States.
Adam B OrnbergDepartment of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois 60115, United States.
Evgueni E NesterovDepartment of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois 60115, United States.ORCID https://orcid.org/0000-0003-2407-9174
Irina V NesterovaDepartment of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois 60115, United States.ORCID https://orcid.org/0000-0002-5033-5488

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report an innovative design concept for small-molecule fluorescent sensors that are highly selective for protein targets. The sensor's enhanced selectivity stems from a "C-clamping" paradigm where three different binding domains cooperatively interact with a protein target. We established the sensor's performance both

Indexed as

biosensorsEGFR kinasefluorescent imaging probesmultivalent cooperative bindingphthalocyaninestyrosine kinase inhibitors

Identifiers

PMID42064611
PMCPMC13126394

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.