Evidence map›Paper›PMID 42064607›Full record

ArticleChemical & biomedical imaging2026

Ion Beam Imaging Shows Selective Thallium-201 Uptake in Cell Nuclei: Impact on Cellular Dosimetry and Radiotoxicity of Auger Electron Emitters.

Katarzyna M Wulfmeier, Paul M D Gape, Catia Costa, Pedro Machado, Theodora Stewart, Raymond M Reilly, Melanie Bailey, Philip J Blower, Vincenzo Abbate, Samantha Y A Terry

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical & biomedical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Bioimaging of Metals.Chemical & biomedical imaging · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Katarzyna M WulfmeierSchool of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, U.K.ORCID https://orcid.org/0000-0003-4742-4399
Paul M D GapeSchool of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, U.K.
Catia CostaUK National Ion Beam Centre, University of Surrey, Guildford GU2 7XH, U.K.ORCID https://orcid.org/0000-0001-5792-3891
Pedro MachadoCentre for Ultrastructural Imaging, King's College London, London SE1 9RT, U.K.
Theodora StewartLondon Metallomics Facility, King's College London, London SE1 9NH, U.K.
Raymond M ReillyDepartment of Pharmaceutical Sciences, University of Toronto, Toronto, ON M5S 3M2, Canade.ORCID https://orcid.org/0000-0003-1038-7993
Melanie BaileyUK National Ion Beam Centre, University of Surrey, Guildford GU2 7XH, U.K.ORCID https://orcid.org/0000-0001-9050-7910
Philip J BlowerSchool of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, U.K.ORCID https://orcid.org/0000-0001-6290-1590
Vincenzo AbbateInstitute of Pharmaceutical Sciences, King's College London, London SE1 9NH, U.K.ORCID https://orcid.org/0000-0002-3300-0520
Samantha Y A TerrySchool of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, U.K.ORCID https://orcid.org/0000-0002-6497-6681

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thallium-201, a promising candidate for precise targeted radionuclide therapy, emits abundant, radiotoxic, short-range Auger and other secondary electrons, but its subcellular distribution, on which the delivered absorbed radiation dose depends, remains unknown. This study investigates the subcellular localization of unbound

methodsProstate (DU145), ovarian (SKOV3), and lung (A549) cancer cells were exposed to nonradioactive TlCl and imaged using laser ablation-inductively coupled plasma-mass spectrometry, energy-dispersive X-ray spectroscopy combined with transmission electron microscopy, and ion beam analysis (IBA). Absorbed radiation doses to cell nuclei from intracellular

resultsOnly IBA successfully quantified thallium in both the nucleus and cytoplasm, showing selective uptake in the nucleus with nuclear:cytoplasmic concentration ratios of 1.8 ± 1.5 in DU145 cells and 1.8 ± 1.0 in SKOV3 cells. New dose calculations for

conclusionThallium-(I) ions show preferential accumulation in cell nuclei and this could account for the higher toxicity of [

Indexed as

cellular dosimetryion beam analysissubcellular localizationtargeted radionuclide therapythallium-201

Identifiers

PMID42064607
PMCPMC13126381

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.