ArticleChemical & biomedical imaging2026
Spatial Visualization of Secreted Lysyl Oxidase Activity from Single Living Cells via Label-Free Electrochemiluminescence Microscopy.
Article in Chemical & biomedical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Dual-Enhanced Electrochemiluminescence Imaging on a Monolayer Film of Nanoreactors for Probing Cell-Matrix Interaction.Chemical & biomedical imaging · 2026Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Spatially resolved analysis of secreted enzyme activity at the single-cell level is critical for understanding extracellular matrix (ECM) remodeling in cancer. This study introduces a label-free electrochemiluminescence (ECL) microscopy method that visualizes lysyl oxidase (LOX) activity secreted by individual tumor cells with subcellular resolution. The approach integrates ECM-localized enzymatic reactions with ECL signal amplification, where LOX-generated hydrogen peroxide enhances luminol-based ECL without external labels. The resulting ΔECL signal directly maps enzyme activity and its spatial heterogeneity across the pericellular region. This platform enables real-time monitoring of LOX inhibition dynamics, phenotypic classification of LOX activity within a breast cancer cell population, and visualization of asymmetric LOX secretion patterns that guide tumor cell migration. These capabilities offer mechanistic insights into ECM-driven tumor invasion and highlight the utility of ECL imaging for high-content single-cell analysis.
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