ArticleCureus2026
Post-streptococcal Hemophagocytic Lymphohistiocytosis in an Immunocompetent Adult.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Secondary hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening hyperinflammatory syndrome that can occur after acute infection, predominantly caused by viruses. Due to its nonspecific presentation and clinical overlap with conditions like sepsis, HLH is frequently underrecognized in adults. We present the case of an immunocompetent adult admitted with undifferentiated shock, which rapidly progressed to multi-organ failure. Upon further investigation, the patient was diagnosed with HLH, and a comprehensive infectious workup revealed streptococcal pharyngitis as the precipitating cause. This case emphasizes the importance of recognizing HLH in the differential diagnosis in immunocompetent adults with pharyngitis presenting with shock, as early recognition is crucial for timely intervention and improved outcomes. Additionally, we review the current literature to characterize the reported infectious causes of HLH in immunocompetent adults in order to highlight the importance of having a low index of suspicion and conducting a comprehensive infectious workup.
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