ArticleCureus2026
Hepatic Epithelioid Hemangioendothelioma Mimicking Metastatic Carcinoma on Liver Biopsy: A Case Report.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatic epithelioid hemangioendothelioma (HEHE) is a rare malignant vascular tumor that frequently poses a diagnostic challenge due to its close resemblance to metastatic carcinoma, particularly on limited biopsy material. We report the case of a 42-year-old woman who presented with constitutional symptoms and gastrointestinal bleeding. Imaging revealed multiple bilateral hepatic lesions, clinically interpreted as metastases from an unknown primary. The liver biopsy revealed cords and tubular structures composed of epithelioid cells within a reactive hepatic background. Immunohistochemistry revealed isolated CK7 positivity, leading to an initial impression of metastatic carcinoma or intrahepatic cholangiocarcinoma. Extensive clinic-radiological work-up failed to identify a primary malignancy. Review of histology highlighted blister cells and intracytoplasmic vacuoles, and subsequent endothelial marker positivity confirmed the diagnosis of HEHE. This case underscores the importance of recognizing histologic clues and the diagnostic pitfall in HEHE, which can lead to misdiagnosis and inappropriate management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.