ArticleTropical life sciences research2026
Upregulation of Apoptotic Protein and Migration-Inhibitory Effects of Gallic Acid and Methyl Gallate Combined with Cisplatin in HeLa Cervical Cancer Cells.
Article in Tropical life sciences research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The study investigated the effects of gallic acid (GA) and methyl gallate (MG), in combination with cisplatin (CIS), on apoptotic protein expression, antioxidant gene expression and cell migration in HeLa cervical cancer cells. HeLa cells were treated with the combinations CIS-GA and CIS-MG prior to further analysis. The expression of apoptotic proteins (Bax, Bcl-2, caspase-3, caspase-9 and p53) was determined via western blot analysis. Antioxidant gene expression in treated HeLa cells was then assessed using reverse transcription quantitative polymerase chain reaction (RT-qPCR). The migration-inhibitory effect of the compound combinations was assessed using a scratch wound-healing assay. Treatment with CIS-GA significantly upregulated the expression of p53, Bax, caspase-3 and caspase-9, and downregulated the expression of Bcl-2. Results from RT-qPCR revealed downregulation of human catalase (
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