ArticleLife metabolism2026
Reducing the strain on calorie restriction.
Article in Life metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
2 authors.
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Abstract
Calorie restriction (CR) is a nutritional intervention known to delay aging and extend lifespan across a wide range of species, raising the possibility of similar benefits in humans. This apparent universality has been questioned by studies reporting shortened lifespan under CR in certain mouse strains. Here, we provide a short perspective on these conflicting findings. Using simple simulation analyses, we explored the apparent strain-specific effects on CR outcomes. Our results illustrate how experimental factors have confounded previous interpretations and led to overemphasis on genotype effects. Reproducible CR studies are crucial for understanding the true potential of CR as a broadly applicable intervention in aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.