Evidence map›Paper›PMID 42064236›Full record

ArticleBBA advances2026

Structural modification of 5-alkyl-4-phenyl-thiazole-based fatty acid amide hydrolase and soluble epoxide hydrolase inhibitors to alleviate orofacial inflammatory pain in the rat.

Gabrielle Gorostiza, Madison Mercado, Lucy Pavana, Daniel Carr, Cassandra Yuan, Amanda Tsang, Karen Gomez, Ian Minton, Dylan Carrillo, Manuel Berumen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BBA advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Gabrielle GorostizaDepartment of Psychology, California State University, East Bay, Hayward, CA, United States.
Madison MercadoDepartment of Psychology, California State University, East Bay, Hayward, CA, United States.
Lucy PavanaDepartment of Psychology, California State University, East Bay, Hayward, CA, United States.
Daniel CarrDepartment of Psychology, California State University, East Bay, Hayward, CA, United States.
Cassandra YuanDepartment of Chemistry and Biochemistry, California State University, Fullerton, Fullerton, CA, United States.
Amanda TsangDepartment of Chemistry and Biochemistry, California State University, Fullerton, Fullerton, CA, United States.
Karen GomezDepartment of Chemistry and Biochemistry, California State University, Fullerton, Fullerton, CA, United States.
Ian MintonDepartment of Chemistry and Biochemistry, California State University, Fullerton, Fullerton, CA, United States.
Dylan CarrilloDepartment of Chemistry and Biochemistry, California State University, Fullerton, Fullerton, CA, United States.
Manuel BerumenDepartment of Chemistry and Biochemistry, California State University, Fullerton, Fullerton, CA, United States.
Stevan PecicDepartment of Chemistry and Biochemistry, California State University, Fullerton, Fullerton, CA, United States.
Ram KandasamyDepartment of Psychology, California State University, East Bay, Hayward, CA, United States.

Funding

U-RISE at Cal State FullertonT34GM149493 · NIGMS · CALIFORNIA STATE UNIVERSITY FULLERTON · PI MATH P CUAJUNGCO · 2023 to 2026
$1.3M
Designed Multiple Ligands as Non-opioid Analgesics for Treating Chronic PainR16GM149204 · NIGMS · CALIFORNIA STATE UNIVERSITY FULLERTON · PI Stevan Pecic · 2023 to 2026
$650k
Developing multitarget enzyme inhibitors as safe and effective anti-migraine treatmentsR16GM150781 · NIGMS · CALIFORNIA STATE UNIVERSITY HAYWARD · PI Ram Kandasamy · 2023 to 2026
$476k
NIGMS NIH HHS R16 GM149204NIGMS NIH HHS R16 GM150781NIGMS NIH HHS T34 GM149493
6 · The paper itself

Abstract

Orofacial pain is difficult to manage. Treatments like nonsteroidal anti-inflammatory drugs (NSAIDs), and serotonin agonists provide limited relief or produce side effects. These limitations highlight the need for alternative strategies that reduce orofacial pain without adverse effects. One approach is polypharmacology, where a single compound modulates multiple targets involved in pain. Fatty acid amide hydrolase (FAAH) and soluble epoxide hydrolase (sEH) are regulators of pain that can be targeted simultaneously to enhance antinociceptive efficacy. We previously reported that the 4-phenylthiazole-based dual FAAH/sEH inhibitor

Indexed as

Enzyme inhibitionFormalinMolecular modelingPolypharmacologyStructure-activity relationship studies

Identifiers

PMID42064236
PMCPMC13125159

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.