Evidence map›Paper›PMID 42064225›Full record

ArticleKidney international reports2026

Case-Control and Longitudinal Study of Sex Steroids in Male Patients with CKD Before and After Kidney Transplantation.

Karel David, Nick Narinx, Bjorn Meijers, Leen Antonio, Henriette de Loor, Frank Claessens, Dirk Vanderschueren, Dirk Kuypers, Maarten Naesens, Brigitte Decallonne and 1 more

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Article in Kidney international reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Karel DavidDepartment of Chronic Diseases and Metabolism, Laboratory of Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium.
Nick NarinxDepartment of Chronic Diseases and Metabolism, Laboratory of Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium.
Bjorn MeijersDepartment of Microbiology, Immunology and Transplantation, Nephrology and Renal Transplantation Research Group, KU Leuven, Leuven, Belgium.
Leen AntonioDepartment of Chronic Diseases and Metabolism, Laboratory of Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium.
Henriette de LoorDepartment of Microbiology, Immunology and Transplantation, Nephrology and Renal Transplantation Research Group, KU Leuven, Leuven, Belgium.
Frank ClaessensDepartment of Cellular and Molecular Medicine, Laboratory of Molecular Endocrinology, KU Leuven, Leuven, Belgium.
Dirk VanderschuerenDepartment of Chronic Diseases and Metabolism, Laboratory of Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium.
Dirk KuypersDepartment of Microbiology, Immunology and Transplantation, Nephrology and Renal Transplantation Research Group, KU Leuven, Leuven, Belgium.
Maarten NaesensDepartment of Microbiology, Immunology and Transplantation, Nephrology and Renal Transplantation Research Group, KU Leuven, Leuven, Belgium.
Brigitte DecallonneDepartment of Chronic Diseases and Metabolism, Laboratory of Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium.
Pieter EvenepoelDepartment of Microbiology, Immunology and Transplantation, Nephrology and Renal Transplantation Research Group, KU Leuven, Leuven, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Sex steroids in male patients decrease along with the progression of chronic kidney disease (CKD) and are associated with worse outcomes. This study aimed to increase the knowledge of the pathophysiology of biochemical hypogonadism in male CKD and its reversibility after kidney transplantation (KT). Methods: We comprehensively mapped the hypothalamic-pituitary-gonadal (HPG) axis in 120 male patients (age 65 yrs, body mass index [BMI]: 26.8 kg/m Results: Hypogonadism is prevalent in CKD and is characterized by depressed T/LH ratio (1.75 [0.71-2.96] vs. 3.99 [2.39-5.20], Conclusion: Male patients with CKD showed low T/LH and inhibin B/FSH ratios pointing towards testicular failure as underlying pathophysiological mechanism. Male CKD can be considered a state of premature testicular ageing. Leydig cell function rapidly recovered after KT suggesting a functional cause of CKD-induced hypogonadism. In contrast, Sertoli cell function showed a deterioration, especially in the early post-transplant period.

Indexed as

chronic kidney diseasehypogonadismkidney transplantationsex steroidstestosterone

Identifiers

PMID42064225
PMCPMC13127329

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