ArticleFrontiers in pain research (Lausanne, Switzerland)2026
Exploring pain-motor dynamics: preliminary insights through exploration of descending inhibition and corticospinal excitability.
Article in Frontiers in pain research (Lausanne, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Conditioned pain modulation, cortical imbalance, and arthrogenic muscle inhibition: an integrative model with implications for exercise in chronic pain.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
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3 authors.
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Abstract
Introduction: Previous studies have linked endogenous pain modulation and corticospinal excitability (CSE), but methodological limitations and overlooking psychological factors may have constrained interpretations. This study aimed to evaluate the interaction between CSE excitability in different muscles and endogenous pain modulation, and to determine whether kinesiophobia and pain catastrophizing modulate this interaction. Methods: Twenty-one pain-free participants completed questionnaires on kinesiophobia and pain catastrophizing. Conditioned pain modulation (CPM) was used to assess endogenous pain modulation. Transcranial magnetic stimulation was used to assess the pain-induced modulation in CSE excitability, focusing on slope, S Results: A significant correlation was found between the plateau of the AD input-output curves measured at baseline (pain-free condition) and CPM responses (r Discussion: These findings underscore the complex interplay between corticospinal projections, pain modulation, and psychological factors, reinforcing the need for further investigation.
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