Evidence map›Paper›PMID 42064197›Full record

ArticlePrecision chemistry2026

Computational Insights into Divergent Pd-Catalyzed Oxidations with Oxone: Unveiling Dual Wacker and Oxo-Hydroxylation Pathways.

Zhuanzhuan Su, Liping Chen, Shuaizhong Zhang, Xianwen Zeng, Shuai Zhang, Yuchen Yang, Xue Wang, Wenjie Lan, Zhijie Chen, Yuehong Zou and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Precision chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zhuanzhuan SuGannan Medical University, Ganzhou 341000, Jiangxi province, China.
Liping ChenGanzhou People's Hospital, Ganzhou 341000, Jiangxi province, China.
Shuaizhong ZhangGannan Medical University, Ganzhou 341000, Jiangxi province, China.
Xianwen ZengGannan Medical University, Ganzhou 341000, Jiangxi province, China.
Shuai ZhangKey Laboratory of Green and Healthy Livestock and Poultry Breeding Technology of Jiangxi Education Institutes, Ganzhou polytechnic college, Ganzhou 341000, Jiangxi province, China.
Yuchen YangKey Laboratory of Green and Healthy Livestock and Poultry Breeding Technology of Jiangxi Education Institutes, Ganzhou polytechnic college, Ganzhou 341000, Jiangxi province, China.
Xue WangKey Laboratory of Green and Healthy Livestock and Poultry Breeding Technology of Jiangxi Education Institutes, Ganzhou polytechnic college, Ganzhou 341000, Jiangxi province, China.
Wenjie LanKey Laboratory of Green and Healthy Livestock and Poultry Breeding Technology of Jiangxi Education Institutes, Ganzhou polytechnic college, Ganzhou 341000, Jiangxi province, China.
Zhijie ChenKey Laboratory of Green and Healthy Livestock and Poultry Breeding Technology of Jiangxi Education Institutes, Ganzhou polytechnic college, Ganzhou 341000, Jiangxi province, China.
Yuehong ZouKey Laboratory of Green and Healthy Livestock and Poultry Breeding Technology of Jiangxi Education Institutes, Ganzhou polytechnic college, Ganzhou 341000, Jiangxi province, China.
Qingqing NieKey Laboratory of Green and Healthy Livestock and Poultry Breeding Technology of Jiangxi Education Institutes, Ganzhou polytechnic college, Ganzhou 341000, Jiangxi province, China.
Wenqiang CaoKey Laboratory of Green and Healthy Livestock and Poultry Breeding Technology of Jiangxi Education Institutes, Ganzhou polytechnic college, Ganzhou 341000, Jiangxi province, China.
Jinquan ZhangGannan Medical University, Ganzhou 341000, Jiangxi province, China.
Ziyan MengKey Laboratory of Green and Healthy Livestock and Poultry Breeding Technology of Jiangxi Education Institutes, Ganzhou polytechnic college, Ganzhou 341000, Jiangxi province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pd-(II)-catalyzed Wacker oxidation represents a robust and attractive route to methyl ketones from terminal alkenes in modern organic synthesis. In this work, we report a tunable oxidation system that employs oxone (potassium peroxymonosulfate) as a green oxidant and di-(pyridin-2-yl)-amine as an effective ligand. Notably, the presence of water triggers a mechanistic divergence from the conventional Wacker-type oxidation to a previously unrecognized radical pathway, enabling selective access to α-hydroxy ketones. Combined experimental and computational studies confirm that methyl ketones are generated via the classical 1,2-hydride migration, whereas α-hydroxy ketones arise through a radical mechanism pathway followed by an OAc

Indexed as

ligandoxo-hydroxylationoxonePd(II)-catalyzedWacker oxidation

Identifiers

PMID42064197
PMCPMC13126367

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.