ArticleMayo Clinic proceedings. Innovations, quality & outcomes2026
Temporal Trends in Direct-Acting Oral Anticoagulants Use Among Patients at Extremes of Body Weight: Insight From PINNACLE Registry.
Article in Mayo Clinic proceedings. Innovations, quality & outcomes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To describe temporal changes in direct oral anticoagulant (DOAC) use across the range of body mass index (BMI) and understand factors associated with its use. Patients and Methods: Outpatients with atrial fibrillation (AF) eligible for systemic anticoagulation in the PINNACLE Registry (January 1st, 2014-September 30th, 2021) were identified, and mixed-effects logistic regression was used to assess the association between DOAC use and BMI, after adjusting for patient characteristics, with an interaction between BMI and calendar year to describe temporal changes in practice. Results: Of 950,644 patients with nonvalvular AF with a CHA Conclusion: Despite limited safety and efficacy evidence for DOAC use in underweight and obese patients with nonvalvular AF, only modest differences exist in its use and growth over time. These data underscore the importance of future research in underweight and obese patients.
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