ReviewMetabolism open2026
Influence of metabolic syndrome on infertility: A review.
Review in Metabolism open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Obesity alters the estrogen-induced luteinizing hormone surge in ovariectomized ewes†.Biology of reproduction · 2026Article
- BMI and idiopathic infertility drive polarized redox phenotypes in human follicular fluid.Frontiers in endocrinology · 2026Article
- New Insight Into Male Infertility: Deviation From Basic Tenets of Life.Oxidative medicine and cellular longevity · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Metabolic Syndrome (MetS) is a cluster of metabolic abnormalities including abdominal obesity, impaired glucose metabolism, hypertriglyceridemia, low high-density lipoprotein (HDL) cholesterol, and hypertension. It is diagnosed when at least three of these five criteria are present. Individuals with MetS are at increased risk of developing type 2 diabetes mellitus and cardiovascular disease. Beyond these well-established complications, infertility has emerged as an underrecognized consequence of metabolic dysfunction. Infertility, defined as failure to achieve pregnancy after one year of regular unprotected intercourse, affects approximately 10-15% of couples worldwide, with nearly 20% of cases classified as idiopathic. Objective: This review aims to examine the impact of metabolic syndrome and its components on male and female infertility and to highlight the potential mechanisms linking metabolic disturbances with impaired reproductive function. Methods: A narrative review of current literature was conducted, focusing on the relationship between metabolic syndrome components - obesity, dyslipidemia, hyperinsulinemia, and hypertension - and reproductive health outcomes. Evidence from clinical, epidemiological, and experimental studies evaluating reproductive dysfunction in both males and females was analyzed. Conclusion: Metabolic syndrome exerts significant adverse effects on reproductive health in both women and men. In women, it is associated with reduced ovulation, impaired oocyte competence, diminished follicular reserve, anovulation, and increased risk of ovarian pathology. In men, MetS contributes to reduced sperm count, impaired sperm motility and viability, poor semen quality, erectile dysfunction, and prostate-related disorders. Early identification and proper management of metabolic syndrome may play a crucial role in reducing the burden. Addressing metabolic abnormalities through lifestyle modification and appropriate medical interventions could improve reproductive outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.