ArticleJournal of oral and maxillofacial pathology : JOMFP
Discerning the vascular transition in oral cancer: Comparative study of CD105 expression in normal, premalignant and malignant oral epithelium.
Article in Journal of oral and maxillofacial pathology : JOMFP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Oral squamous cell carcinoma (OSCC), which accounts for over 90% of oral malignancies in India, presents a significant public health concern due to its high incidence and mortality. Angiogenesis is a critical component of tumour progression and metastasis, and cluster of differentiation 105 (CD105) (Endoglin)-a transmembrane glycoprotein expressed on activated endothelial cells-is considered a more specific marker of tumour neoangiogenesis than conventional pan-endothelial markers (e.g. CD34 and CD31). Aim: To assess and compare CD105-based microvessel density (MVD) in normal oral mucosa, oral potentially malignant disorders (OPMDs) and OSCC samples, evaluating endoglin potential as a specific neoangiogenesis marker for early detection and prognostic assessment in oral carcinogenesis. Materials and Methods: Archived formalin-fixed, paraffin-embedded tissue samples from 45 cases (15 OSCC, 15 OPMDs and 15 normal mucosa) were subjected to anti-CD105 immunohistochemical staining. MVD was quantified using the hot-spot method under high-power magnification across five fields per sample. Statistical comparisons among groups were performed using one-way analysis of variance (ANOVA) followed by Results: A progressive and statistically significant increase in mean microvessel density was observed: normal mucosa (23.07 ± 10.61), OPMDs (36.07 ± 15.92) and reaching the highest level in OSCC (69.23 ± 17.63). All intergroup differences were highly significant ( Conclusion: These findings underscore endoglin's value as a sensitive immunohistochemical marker for detecting neoangiogenesis. Its progressive increase in MVD from normal through potentially malignant tissue to carcinoma highlights its potential role in early detection and prognostic evaluation of oral carcinogenic progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.