ArticleJournal of oral and maxillofacial pathology : JOMFP
Assessment of salivary malondialdehyde level as oxidative stress marker in oral lichen planus and its correlation with psychological stress.
Article in Journal of oral and maxillofacial pathology : JOMFP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Oral lichen planus (OLP) is a chronic autoimmune mucocutaneous disorder influenced by oxidative stress (OS) and psychological factors. Malondialdehyde (MDA), a lipid peroxidation product, serves as a reliable non-invasive biomarker of OS, measurable in saliva. While elevated MDA levels have been reported in OLP, limited research has explored its association with psychological stress. This study aimed to assess salivary MDA levels in OLP patients and correlate them with psychological parameters. Materials and Methods: This cross-sectional study included 25 clinically and histopathologically confirmed OLP patients and 25 age- and sex-matched healthy controls. Unstimulated saliva samples were collected and analysed for MDA using ELISA. Psychological stress was evaluated using the Depression, Anxiety, and Stress Scale-21 scale. Data were analysed using an independent Results: Mean salivary MDA levels were significantly higher in the OLP group (3.58 ± 1.69 nmol/mL) than in controls (1.73 ± 1.32 nmol/mL) ( Conclusion: Salivary MDA is a valid marker of OS in OLP. While psychological stress levels were significantly higher in OLP patients, no direct correlation was found between OS and psychological parameters.
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