ArticleJournal of oral and maxillofacial pathology : JOMFP
Assessment of collagen birefringence in different grades of oral squamous cell carcinoma using Picrosirius red - polarizing microscopy and comparison with Picrosirius red - Fast green stain.
Article in Journal of oral and maxillofacial pathology : JOMFP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Oral squamous cell carcinoma (OSCC) is among the most common cancers globally, with significant prevalence in India. While OSCC is primarily an epithelial malignancy, its interaction with the surrounding stroma influences tumour progression. The stromal response may facilitate invasion via collagen degradation or inhibit it through desmoplasia. Aims and Objectives: To comparatively evaluate stromal collagen alterations in different histological grades of OSCC using Picrosirius Red and PSR-Fast Green staining with emphasis on staining characteristics, birefringence patterns, and morphometric analysis. Materials and Methods: A total of 60 archival OSCC specimens comprising well-differentiated ( Results: Well-differentiated OSCC displayed thick, parallel, dense collagen fibres with strong orange-red birefringence. Moderately differentiated OSCC exhibited intermediate features with mixed birefringence. Poorly differentiated OSCC showed thin, disorganized, loosely arranged collagen fibres with weak green birefringence under polarized light. PSR-Fast Green staining offered comparable results with enhanced bright-field contrast. Conclusion: Collagen architecture and birefringence diminish with increasing OSCC grade, indicating progressive stromal degradation that likely facilitates tumour invasion. Evaluating stromal collagen using PSR and PSR-Fast Green may provide diagnostic and prognostic value in OSCC.
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