ArticleJournal of oral and maxillofacial pathology : JOMFP
Expression profile of miR-99a and miR-218 across oral submucous fibrosis and oral squamous cell carcinoma.
Article in Journal of oral and maxillofacial pathology : JOMFP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Differential expression of hsa-miR-21-5p and hsa-miR-26a-5p in oral squamous cell carcinoma: A Single Centre pilot study.Molecular biology reports · 2026Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Oral squamous cell carcinoma (OSCC) remains a major public health concern in India, often preceded by Oral Submucous Fibrosis (OSMF), a chronic progressive condition with malignant potential. MicroRNAs (miRNAs), including miR-99a and miR-218, are critical post-transcriptional regulators implicated in tumorigenesis and fibrosis. However, limited studies have assessed their expression profiles across the OSCC-OSMF continuum, particularly in Indian cohorts. This study investigates the expression patterns of miR-99a and miR-218 and their correlation with clinical and histopathological variables. Materials and Methods: FFPE tissue samples from 15 OSCC patients, 15 OSMF patients and 10 healthy controls were analysed. Sections were deparaffinized and total RNA was extracted with DNase treatment. Reverse transcription and SYBR Green-based qRT-PCR were performed to quantify miR-99a and miR-218 expression. Ct values were normalized to U6 snRNA and fold changes were calculated using the 2^ Results: miR-99a was significantly downregulated in OSCC (mean Ct: 29.3 ± 1.4) and OSMF (mean Ct: 28.4 ± 1.1) compared with normal mucosa (mean Ct: 26.1 ± 1.5; Conclusion: Distinct expression patterns of miR-99a and miR-218 across OSCC and OSMF suggest their roles in regulating epithelial dysplasia, fibrosis and tumor progression. These miRNAs hold promise as minimally invasive biomarkers for early diagnosis, prognosis and personalized therapeutic targeting in oral potentially malignant and malignant disorders.
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