ArticleJournal of oral and maxillofacial pathology : JOMFP
Matrix metalloproteinase-9 expression in oral potentially malignant disorders and oral squamous cell carcinoma - An immunohistochemical study.
Article in Journal of oral and maxillofacial pathology : JOMFP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Oral squamous cell carcinoma (OSCC) is the 3 Materials and Methods: This retrospective cross-sectional study included five study groups comprising histopathologically diagnosed cases of oral lichen planus (10 cases), oral submucous fibrosis (10 cases), oral leukoplakia (10 cases), OSCC (10 cases), and normal oral mucosa (10 cases). Results: After evaluation and comparison of the area and intensity of staining of MMP-9 among the groups, it is significantly appreciated in OSCC (100% positive expression) and OPMD disorders when compared to the mucosa free of lesions. Conclusion: MMP-9 can be considered a reliable marker to assess invasion and prognosis in OSCC. The expression of MMP-9 in OPMDs suggests alteration in the epithelial cells, thereby prompting early management to curb lesion carcinogenesis.
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